Detalhe da pesquisa
1.
Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates.
Bioorg Chem
; 147: 107421, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38714118
2.
Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR.
Molecules
; 28(3)2023 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36770971
3.
Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists.
Bioorg Med Chem Lett
; 30(19): 127441, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32736080
4.
Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.
Bioorg Med Chem Lett
; 30(12): 127204, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32334911
5.
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.
Bioorg Med Chem Lett
; 29(16): 2265-2269, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31257087
6.
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg Med Chem Lett
; 28(2): 85-93, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29233651
7.
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
Bioorg Med Chem Lett
; 27(14): 3101-3106, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28539220
8.
Discovery of highly potent, selective, covalent inhibitors of JAK3.
Bioorg Med Chem Lett
; 27(20): 4622-4625, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927786
9.
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
Bioorg Med Chem Lett
; 24(24): 5721-5726, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453808
10.
Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2.
J Med Chem
; 66(21): 15006-15024, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37856840
11.
Reliability and validity of the repetitive behavior scale-revised for young Chinese children with autism spectrum disorder in Jiangxi Province.
Front Pediatr
; 10: 939841, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36160810
12.
[A study on individual internal fixation with steel plate according to 3D reconstruction of CT images and Ugnx, Pro/E machining method].
Zhongguo Yi Liao Qi Xie Za Zhi
; 34(2): 89-91, 93, 2010 Mar.
Artigo
em Zh
| MEDLINE | ID: mdl-20540287
13.
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J Med Chem
; 63(23): 15050-15071, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33261314
14.
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
ACS Med Chem Lett
; 10(3): 367-373, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891142
15.
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Bioorg Med Chem Lett
; 18(6): 1958-62, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18282708
16.
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
Bioorg Med Chem Lett
; 18(5): 1577-82, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242982
17.
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorg Med Chem Lett
; 18(1): 241-6, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032037
18.
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 18(2): 694-9, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18061445
19.
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
J Med Chem
; 45(23): 4954-7, 2002 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12408705
20.
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorg Med Chem Lett
; 17(1): 266-71, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17027261