Detalhe da pesquisa
1.
Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate.
Biochemistry
; 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306231
2.
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates.
Am J Hum Genet
; 104(4): 625-637, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30879639
3.
Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4-/- mouse model of PFIC3.
J Hepatol
; 74(6): 1416-1428, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33340584
4.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
5.
mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency.
Mol Ther
; 27(7): 1242-1251, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31056400
6.
High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.
Proc Natl Acad Sci U S A
; 112(49): 15196-201, 2015 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26598693
7.
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc Natl Acad Sci U S A
; 109(29): 11788-93, 2012 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22745160
8.
The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 9): 1717-25, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23999295
9.
Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Bioorg Med Chem Lett
; 23(24): 6610-5, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239188
10.
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg Med Chem Lett
; 23(5): 1486-92, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23352510
11.
Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humans.
J Biol Chem
; 286(21): 19118-26, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454522
12.
Discovery of a novel series of 4-quinolone JNK inhibitors.
Bioorg Med Chem Lett
; 22(24): 7381-7, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142618
13.
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.
Bioorg Med Chem Lett
; 21(6): 1795-801, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316218
14.
Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Bioorg Med Chem Lett
; 20(20): 5984-7, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20832307
15.
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia.
Nat Commun
; 11(1): 5339, 2020 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33087718
16.
Systematic literature review and meta-analysis on the epidemiology of methylmalonic acidemia (MMA) with a focus on MMA caused by methylmalonyl-CoA mutase (mut) deficiency.
Orphanet J Rare Dis
; 14(1): 84, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31023387
17.
Systematic literature review and meta-analysis on the epidemiology of propionic acidemia.
Orphanet J Rare Dis
; 14(1): 40, 2019 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30760309
18.
Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia.
EBioMedicine
; 45: 519-528, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31303505
19.
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria.
Nat Med
; 24(12): 1899-1909, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297912
20.
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Protein Sci
; 26(2): 152-162, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27727493