Detalhe da pesquisa
1.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Bioorg Med Chem Lett
; 27(4): 1062-1069, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28131713
2.
Comparison of the intrinsic vasorelaxant and inotropic effects of the antiarrhythmic agents vernakalant and flecainide in human isolated vascular and cardiac tissues.
J Cardiovasc Pharmacol
; 61(3): 226-32, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23188129
3.
P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.
Bioorg Med Chem Lett
; 21(5): 1532-5, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295466
4.
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Bioorg Med Chem Lett
; 21(5): 1536-40, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295467
5.
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
J Pharmacol Exp Ther
; 333(1): 152-60, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20065019
6.
Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.
J Cardiovasc Pharmacol
; 56(5): 518-25, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20729756
7.
Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries.
J Cardiovasc Pharmacol
; 55(5): 518-21, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20164785
8.
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
Bioorg Med Chem Lett
; 20(8): 2493-6, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20304642
9.
Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
J Pharmacol Exp Ther
; 328(2): 571-8, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18997059
10.
Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor.
Neurosci Res
; 63(1): 10-6, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18951929
11.
The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
J Cardiovasc Pharmacol
; 53(6): 474-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19430309
12.
Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure.
J Pharmacol Exp Ther
; 324(1): 322-30, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17967939
13.
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
J Med Chem
; 50(4): 807-19, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17249648
14.
An improved automated method to quantitate infarct volume in triphenyltetrazolium stained rat brain sections.
J Pharmacol Toxicol Methods
; 56(3): 339-43, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17596972
15.
Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments in Mice.
Comp Med
; 67(4): 330-334, 2017 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830579
16.
Early echocardiographic predictors of outcomes in the mouse transverse aortic constriction heart failure model.
J Pharmacol Toxicol Methods
; 84: 93-101, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27956205
17.
Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model.
SAGE Open Med
; 5: 2050312117700057, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28491305
18.
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
J Med Chem
; 49(24): 6954-7, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125248
19.
9-hydroxyazafluorenes and their use in thrombin inhibitors.
J Med Chem
; 48(7): 2282-93, 2005 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801822
20.
Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N-methyl-D-aspartate receptor antagonist.
Pharmacol Res Perspect
; 3(6): e00198, 2015 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27022470