Detalhe da pesquisa
1.
Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.
J Pharmacol Exp Ther
; 382(3): 266-276, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779860
2.
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Bioorg Med Chem Lett
; 23(24): 6588-92, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239482
3.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23089526
4.
Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
BMC Genomics
; 12: 281, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21631939
5.
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis.
MAbs
; 12(1): 1709322, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31924119
6.
Non-neutralizing antibodies increase endogenous circulating Ang1 levels.
MAbs
; 10(8): 1260-1268, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30199300
7.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196621
8.
Generation and characterization of a monoclonal IgG antibody to polyethylene glycol.
Hybridoma (Larchmt)
; 26(3): 168-72, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17600499
9.
PDE-10A inhibitors as insulin secretagogues.
Bioorg Med Chem Lett
; 17(10): 2869-73, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17400452
10.
Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist.
J Biol Chem
; 281(18): 12506-15, 2006 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16505481
11.
Discovery of 5-hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists.
Bioorg Med Chem Lett
; 12(3): 461-4, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11814820
12.
Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis.
Bioorg Med Chem Lett
; 12(9): 1303-6, 2002 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-11965376
13.
Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide.
J Biol Chem
; 278(12): 10273-81, 2003 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12525492
14.
Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists.
Bioorg Med Chem Lett
; 12(23): 3421-4, 2002 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12419375