Pesquisa | Biblioteca Virtual em Saúde

1.

Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.

Rapiteanu, Radu; Karagyozova, Tina; Zimmermann, Natalie; Singh, Kuljit; Wayne, Gareth; Martufi, Matteo; Belyaev, Nikolai N; Hessel, Edith M; Michalovich, David; Macarron, Ricardo; Rowan, Wendy C; Cairns, William J; Roger, Jan; Betts, Joanna; Beinke, Soren; Maratou, Klio.

Eur Respir J ; 55(5)2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32060058

2.

Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.

Hummel, Joshua R; Xiao, Kai-Jiong; Yang, Jeffrey C; Epling, Leslie B; Mukai, Ken; Ye, Qinda; Xu, Meizhong; Qian, Dingquan; Huo, Lu; Weber, Michael; Roman, Valerie; Lo, Yvonne; Drake, Katherine; Stump, Kristine; Covington, Maryanne; Kapilashrami, Kanishk; Zhang, Guofeng; Ye, Min; Diamond, Sharon; Yeleswaram, Swamy; Macarron, Ricardo; Deller, Marc C; Wee, Susan; Kim, Sunkyu; Wang, Xiaozhao; Wu, Liangxing; Yao, Wenqing.

J Med Chem ; 67(4): 3112-3126, 2024 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-38325398

3.

Chemical libraries: How dark is HTS dark matter?

Macarron, Ricardo.

Nat Chem Biol ; 11(12): 904-5, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26479440

4.

Process validation and screen reproducibility in high-throughput screening.

Coma, Isabel; Clark, Liz; Diez, Emilio; Harper, Gavin; Herranz, Jesus; Hofmann, Glenn; Lennon, Mark; Richmond, Nicola; Valmaseda, Manuel; Macarron, Ricardo.

J Biomol Screen ; 14(1): 66-76, 2009 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19171922

5.

Design and implementation of high-throughput screening assays.

Macarrón, Ricardo; Hertzberg, Robert P.

Methods Mol Biol ; 565: 1-32, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19551355

6.

Nuisance Compounds, PAINS Filters, and Dark Chemical Matter in the GSK HTS Collection.

Chakravorty, Subhas J; Chan, James; Greenwood, Marie Nicole; Popa-Burke, Ioana; Remlinger, Katja S; Pickett, Stephen D; Green, Darren V S; Fillmore, Martin C; Dean, Tony W; Luengo, Juan I; Macarrón, Ricardo.

SLAS Discov ; 23(6): 532-545, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29699447

7.

Applications of CRISPR genome editing technology in drug target identification and validation.

Lu, Quinn; Livi, George P; Modha, Sundip; Yusa, Kosuke; Macarrón, Ricardo; Dow, David J.

Expert Opin Drug Discov ; 12(6): 541-552, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28388235

8.

Critical review of the role of HTS in drug discovery.

Macarron, Ricardo.

Drug Discov Today ; 11(7-8): 277-9, 2006 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-16580969

9.

The effect of triton concentration on the activity of undecaprenyl pyrophosphate synthase inhibitors.

Li, Hu; Huang, Jianzhong; Jiang, Xinhe; Seefeld, Mark; McQueney, Michael; Macarron, Ricardo.

J Biomol Screen ; 8(6): 712-5, 2003 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-14711397

10.

A standard operating procedure for assessing liquid handler performance in high-throughput screening.

Taylor, Paul B; Ashman, Stephen; Baddeley, Stuart M; Bartram, Stacy L; Battle, Clive D; Bond, Brian C; Clements, Yvonne M; Gaul, Nathan J; McAllister, W Elliot; Mostacero, Juan A; Ramon, Fernando; Wilson, Jamie M; Hertzberg, Robert P; Pope, Andrew J; Macarron, Ricardo.

J Biomol Screen ; 7(6): 554-69, 2002 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-14599354

11.

Novel antibacterials: a genomics approach to drug discovery.

Chan, Pan F; Macarron, Ricardo; Payne, David J; Zalacain, Magdalena; Holmes, David J.

Curr Drug Targets Infect Disord ; 2(4): 291-308, 2002 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-12570737

12.

Design and implementation of high throughput screening assays.

Macarrón, Ricardo; Hertzberg, Robert P.

Methods Mol Biol ; 190: 1-29, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12029816

13.

Design and implementation of high throughput screening assays.

Macarrón, Ricardo; Hertzberg, Robert P.

Mol Biotechnol ; 47(3): 270-85, 2011 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-20865348

14.

Impact of high-throughput screening in biomedical research.

Macarron, Ricardo; Banks, Martyn N; Bojanic, Dejan; Burns, David J; Cirovic, Dragan A; Garyantes, Tina; Green, Darren V S; Hertzberg, Robert P; Janzen, William P; Paslay, Jeff W; Schopfer, Ulrich; Sittampalam, G Sitta.

Nat Rev Drug Discov ; 10(3): 188-95, 2011 03.

Artigo em Inglês | MEDLINE | ID: mdl-21358738

15.

Enhancements of screening collections to address areas of unmet medical need: an industry perspective.

Drewry, David H; Macarron, Ricardo.

Curr Opin Chem Biol ; 14(3): 289-98, 2010 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-20413343

16.

Ultra high quality uHTS.

Macarrón, Ricardo.

Drug Discov Today ; 8(20): 923, 2003 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-14554154

17.

Yin and Yang in medicinal chemistry: what does drug-likeness mean?

Macarrón, Ricardo; Luengo, Juan I.

Future Med Chem ; 3(5): 505-7, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21526891

18.

Identification of novel isoform-selective inhibitors within class I histone deacetylases.

Hu, Erding; Dul, Edward; Sung, Chiu-Mei; Chen, Zunxuan; Kirkpatrick, Robert; Zhang, Gui-Feng; Johanson, Kyung; Liu, Ronggang; Lago, Amparo; Hofmann, Glenn; Macarron, Ricardo; de los Frailes, Maite; Perez, Paloma; Krawiec, John; Winkler, James; Jaye, Michael.

J Pharmacol Exp Ther ; 307(2): 720-8, 2003 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-12975486

19.

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Dhanak, Dashyant; Duffy, Kevin J; Johnston, Victor K; Lin-Goerke, Juili; Darcy, Michael; Shaw, Antony N; Gu, Baohua; Silverman, Carol; Gates, Adam T; Nonnemacher, Michael R; Earnshaw, David L; Casper, David J; Kaura, Arun; Baker, Audrey; Greenwood, Cathy; Gutshall, Lester L; Maley, Derrick; DelVecchio, Alfred; Macarron, Ricardo; Hofmann, Glenn A; Alnoah, Zaid; Cheng, Hung-Yuan; Chan, George; Khandekar, Sanjay; Keenan, Richard M; Sarisky, Robert T.

J Biol Chem ; 277(41): 38322-7, 2002 Oct 11.

Artigo em Inglês | MEDLINE | ID: mdl-12167642

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Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.

Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.

Chemical libraries: How dark is HTS dark matter?

Process validation and screen reproducibility in high-throughput screening.

Design and implementation of high-throughput screening assays.

Nuisance Compounds, PAINS Filters, and Dark Chemical Matter in the GSK HTS Collection.

Applications of CRISPR genome editing technology in drug target identification and validation.

Critical review of the role of HTS in drug discovery.

The effect of triton concentration on the activity of undecaprenyl pyrophosphate synthase inhibitors.

A standard operating procedure for assessing liquid handler performance in high-throughput screening.

Novel antibacterials: a genomics approach to drug discovery.

Design and implementation of high throughput screening assays.

Design and implementation of high throughput screening assays.

Impact of high-throughput screening in biomedical research.

Enhancements of screening collections to address areas of unmet medical need: an industry perspective.

Ultra high quality uHTS.

Yin and Yang in medicinal chemistry: what does drug-likeness mean?

Identification of novel isoform-selective inhibitors within class I histone deacetylases.

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.