Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children.

There is no evidence evaluating the IL10 epigenetic upregulation among mestizo children in a high-altitude Andean city in Latin America. OBJECTIVE: To identify polymorphisms and methylation profiles in the IL10 gene associated with asthma in children aged 5 to 11. METHODS: A case-control study was conducted with asthmatic and non-asthmatic children aged 5 to 11 years in Cuenca-Ecuador. Data on allergic diseases and risk factors were collected through a questionnaire for parents. Atopy was measured by skin prick test (SPT) to relevant aeroallergens. Three IL10 single nucleotide polymorphisms were evaluated in all participants, and methylation analysis was performed in 54 participants. Association between risk factors, allergic diseases and genetic factors were estimated using multivariate logistic regression. RESULTS: The results of polymorphisms showed no differences between cases and controls when comparing the SNPs rs3024495, rs3024496, rs1800896 allelic and genotypic frequencies. In the methylation analysis, no differences in the IL10 methylation profile were found between cases and controls; however, the multivariate analysis showed an association between the mother's smoking habits and the IL10 methylation profile. CONCLUSION: Smoking habit could be essential as an environmental exposure factor in regulating gene expression in children with asthma.

Cistadenoma mucinoso del apéndice cecal en paciente con cuadro clínico de apendicitis aguda operado de apendicetomía por laparoscopia / Report of a Patient Case with a Clinical Picture of Acute Appendicitis, Underwent Emergency Surgery due to Laparoscopic Appendectomy

Resumen Los mucoceles del apéndice son raros, predominan en mujeres y suelen presentarse como una masa palpable en el cuadrante inferior derecho. La mayoría de los pacientes son asintomáticos. El mucocele se define como una dilatación quística de la luz apendicular causada por la acumulación de mucina. Se presenta el caso de un paciente del sexo masculino en la séptima década de la vida, con cuadro clínico de abdomen agudo con sospecha de apendicitis aguda. Se realizó intervención quirúrgica laparoscópica de hemicolectomía tras encontrar hallazgos de tumoración dependiente de colon ascendente (región de ciego), indurada de 80 × 100 mm aproximadamente, realizando hemicolectomía derecha más anastomosis ilecolónica lateroterminal con adecuada evolución postquirúrgica.

Abstract Mucoceles of the appendix are rare, predominate in women and usually present as a palpable mass in the right lower quadrant. Most patients are asymptomatic. The mucocele is defined as a cystic dilatation of the appendicular lumen caused by mucin accumulation. We present the case of a male patient in his seventh decade with clinical symptoms of acute abdomen with suspicion of acute appendicitis, laparoscopic hemicolectomy surgery was performed after finding findings of tumor dependent on ascending colon (blind region), indurated 80 × 100 mm approximately, performing right hemicolectomy plus ileocolonic lateroterminal anastomosis with adequate postoperative evolution.