Detalhe da pesquisa
1.
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg Med Chem Lett
; 27(18): 4370-4376, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830649
2.
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
J Immunol
; 191(5): 2205-16, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23894201
3.
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Nat Commun
; 15(1): 43, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167811
4.
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
J Med Chem
; 65(24): 16589-16621, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455032
5.
Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.
J Med Chem
; 58(12): 5053-74, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25988399
6.
Novel functionalized titanium(IV) benzylidenes for the traceless solid-phase synthesis of indoles.
Org Lett
; 4(1): 75-8, 2002 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-11772094
7.
Solid/solution-phase annulation reagents: single-step synthesis of cyclic amine derivatives.
Angew Chem Int Ed Engl
; 44(36): 5830-3, 2005 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078285
8.
Unusual underlying cause of recurrent vulval abscess.
BMJ Case Rep
; 20102010.
Artigo
em Inglês
| MEDLINE | ID: mdl-22461858
9.
Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin.
J Comb Chem
; 8(1): 132-40, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16398564
10.
Synthesis of 2-substituted benzofurans and indoles using functionalized titanium benzylidene reagents on solid phase.
J Org Chem
; 68(2): 387-401, 2003 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12530864
11.
Teaching junior doctors to recognise child abuse and neglect.
Med Educ
; 37(11): 1046, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14629445