Detalhe da pesquisa
1.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Cell
; 187(10): 2446-2464.e22, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38582079
2.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Cell
; 185(4): 712-728.e14, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35063084
3.
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Hum Mol Genet
; 28(21): 3552-3568, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31428781
4.
The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
J Biol Chem
; 294(13): 4738-4758, 2019 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30709905
5.
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
Hum Mol Genet
; 26(14): 2747-2767, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28453723
6.
Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.
Biochem Soc Trans
; 45(1): 147-154, 2017 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28202668
7.
Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.
Biochem Soc Trans
; 43(3): 390-5, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26009181
8.
Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
iScience
; 25(6): 104476, 2022 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35721463
9.
RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A.
Front Mol Neurosci
; 11: 417, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30483055
10.
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Mol Neurodegener
; 13(1): 3, 2018 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29357897
11.
LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.
Curr Protein Pept Sci
; 18(7): 677-686, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965688
12.
Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.
Curr Neuropharmacol
; 14(3): 238-49, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26517050
13.
Two-Pore Channels and Parkinson's Disease: Where's the Link?
Messenger (Los Angel)
; 5(1-2): 67-75, 2016 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28529828