A new promising approach to urodynamic stress urinary incontinence care can help menopausal women.

Introduction: The goal of this study is to evaluate the effectiveness of single-incision mini-sling in the surgical treatment of postmenopausal urodynamic stress urinary incontinence (SUI) compared to the standard trans-obturator mid-urethral sling. Material and methods: This prospective study was carried out in two tertiary centres; Al-Azhar University Maternity & Urology Hospitals. A total of 120 postmenopausal women with urodynamic SUI were randomized to undergo either single-incision mini-sling (n = 60) or standard trans-obturator mid-urethral sling procedure (n = 60) from May 2019 until Oct 2021. Main outcome measures: efficacy was evaluated utilizing objective cure rate (cough stress test) and subjective cure rate (Sandvik incontinence severity index and International Consultations on Incontinence Questionnaire - Short Form), intraoperative and postoperative complications, and postoperative pain (using a visual analogue scale). Results: The single-incision mini-sling (SIMS) and transobturator tape (TOT) groups had no statistically significant difference in subjective and objective cure rates (p > 0.05). Compared with the transvaginal tape O group, patients in the SIMS group had significantly less postoperative pain, shorter operative duration, and less intraoperative blood loss (all p-values < 0.05). No significant difference in perioperative complications was observed between both groups. Conclusions: Single-incision mini-sling was superior to TOT in postmenopausal as SIMS is of similar effectiveness, more safe and minimally invasive with earlier ambulance.

Microplastics: Occurrences, treatment methods, regulations and foreseen environmental impacts.

Microplastics are a silent threat that represent a high degree of danger to the environment in its different ecosystems and of course will also have an important impact on the health of living organisms. It is evident the need to have effective treatments for their treatment, however this is not a simple task, this as a result of the behavior of microplastics in wastewater treatment plants due to their different types and nature, their long molecular chain, reactivity against water, size, shape and the functional groups they carry. Wastewater treatment plants are at the circumference of the release of these wastes into the environment. They often act as a source of many contaminations, which makes this problem more complex. Challenges such as detection in the current scenario using the latest analytical techniques impede the correct understanding of the problem. Due to microplastics, treatment plants have operational and process stability problems. This review paper will present the in-depth situation of occurrence of microplastics, their detection, conventional and advanced treatment methods as well as implementation of legislations worldwide in a comprehensive manner. It has been observed that no innovative or new technologies have emerged to treat microplastics. Therefore, in this article, technologies targeting wastewater treatment plants are critically analyzed. This will help to understand their fate, but also to develop state-of-the-art technologies or combinations of them for the selective treatment of microplastics. The pros and cons of the treatment methods adopted and the knowledge gaps in legislation regarding their implementation are also comprehensively analyzed. This critical work will offer the development of new strategies to restrict microplastics.

Elevation in wildfire frequencies with respect to the climate change.

Forests have been undergoing through immense pressure due to the factors like human activities; procurement of forest products and climate change which is a major factor influencing this pressure buildup on forests. Climate change and temperature increase caused by anthropogenic activities have notably affected forests and wildlife on a global scale. High temperature increases the soil-water evaporation, resulting in drier soils, and water loss in forest flora. The incidence of forest fires has doubled since 1984 and these are linked to global warming. Drought influences fuel moisture by bringing about physiological changes in forest vegetation leading to forest fires. Forest resilience is hampered because of temperature and drought stress at the developing stage of plant's life cycle leading to the shift in plant species in those areas. Forest fire incidences can be managed with proper management strategies such as sustainable, community and urban forest management. A careful monitoring of stress precursors, subsistence uses of forests, ecological education and planting of near native and new indigenous plant species are the tools that can aid in efficient forest management.

COVID-19 drugs in aquatic systems: a review.

The outbreak of the human coronavirus disease 2019 (COVID-19) has induced an unprecedented increase in the use of several old and repurposed therapeutic drugs such as veterinary medicines, e.g. ivermectin, nonsteroidal anti-inflammatory drugs, protein and peptide therapeutics, disease-modifying anti-rheumatic drugs and antimalarial drugs, antiretrovirals, analgesics, and supporting agents, e.g. azithromycin and corticosteroids. Excretion of drugs and their metabolites in stools and urine release these drugs into wastewater, and ultimately into surface waters and groundwater systems. Here, we review the sources, behaviour, environmental fate, risks, and remediation of those drugs. We discuss drug transformation in aquatic environments and in wastewater treatment systems. Degradation mechanisms and metabolite toxicity are poorly known. Potential risks include endocrine disruption, acute and chronic toxicity, disruption of ecosystem functions and trophic interactions in aquatic organisms, and the emergence of antimicrobial resistance.

Reuse of poor-quality water for sustainable crop production in the changing scenario of climate.

The availability of freshwater is limited for agriculture systems across the globe. A fast-growing population demands need to enhance the food grain production from a limited natural resources. Therefore, researchers and policymakers have been emphasized on the production potential of agricultural crops in a sustainable manner. On the challenging side, freshwater bodies are shrinking with the pace of time further limiting crop production. Poor-quality water may be a good alternative for fresh water in water scarce areas. It should not contain toxic pollutants beyond certain critical levels. Unfortunately, such critical limits for different pollutants as well as permissible quality parameters for different wastewater types are lacking or poorly addressed. Marginal quality water and industrial effluent used in crop production should be treated prior to application in crop field. Hence, safe reuse of wastewater for cultivation of food material is necessary to fulfil the demands of growing population across the globe in the changing scenario of climate.

Green analysis of newly approved binary omeprazole/aspirin mixture in presence of aspirin impurity using ultra-high-performance liquid chromatography and thin-layer chromatography methods.

Two green, simple, and accurate chromatographic methods were developed and validated for the simultaneous determination of omeprazole and aspirin mixture in the presence of salicylic acid, a major impurity of aspirin. Method A is a reversed-phase ultra-high-performance liquid chromatography; the separation was performed on a C18 column, with a mobile phase composed of ethanol:0.1% aqueous solution of triethylamine acidified with orthophosphoric acid (pH 3) (30:70, v/v) at 0.15 mL/min flow rate and 230 nm. Omeprazole, aspirin, and aspirin impurity retention times were 7.47, 4.40, and 5.13 min, respectively. Good linearity was achieved in the concentration ranges of 5-80, 5-85, and 3-50 µg/mL for the three mentioned components, respectively. Method B is thin-layer chromatography (TLC) where silica gel TLC F254 plates were utilized to achieve separation using ethanol:ethyl acetate (2:8, v/v) as a developing system at 240 nm. The resulted Rf values were 0.83, 0.65, and 0.23 for omeprazole, aspirin, and impurity, respectively. The concentration ranges of 0.1-3 µg/band for the three drugs showed good linearity. The proposed methods are eco-friendly and greener when compared to the already reported method (Microchemical Journal, 152, 104350). This is the first use of TLC method for the determination of the three drugs. International Council for Harmonization (ICH) guidelines were followed to ensure the validity of developed methods.

A Camera-Based Position Correction System for Autonomous Production Line Inspection.

Visual inspection is an important task in manufacturing industries in order to evaluate the completeness and quality of manufactured products. An autonomous robot-guided inspection system was recently developed based on an offline programming (OLP) and RGB-D model system. This system allows a non-expert automatic optical inspection (AOI) engineer to easily perform inspections using scanned data. However, if there is a positioning error due to displacement or rotation of the object, this system cannot be used on a production line. In this study, we developed an automated position correction module to locate an object's position and correct the robot's pose and position based on the detected error values in terms of displacement or rotation. The proposed module comprised an automatic hand-eye calibration and the PnP algorithm. The automatic hand-eye calibration was performed using a calibration board to reduce manual error. After calibration, the PnP algorithm calculates the object position error using artificial marker images and compensates for the error to a new object on the production line. The position correction module then automatically maps the defined AOI target positions onto a new object, unless the target position changes. We performed experiments that showed that the robot-guided inspection system with the position correction module effectively performed the desired task. This smart innovative system provides a novel advancement by automating the AOI process on a production line to increase productivity.

COVID-19 transmission, vulnerability, persistence and nanotherapy: a review.

End 2019, the zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), named COVID-19 for coronavirus disease 2019, is the third adaptation of a contagious virus following the severe acute respiratory syndrome coronavirus in 2002, SARS-CoV, and the Middle East respiratory syndrome virus in 2012, MERS-CoV. COVID-19 is highly infectious and virulent compared to previous outbreaks. We review sources, contagious routes, preventive measures, pandemic, outbreak, epidemiology of SARS-CoV, MERS-CoV and SARS-CoV-2 from 2002 to 2020 using a Medline search. We discuss the chronology of the three coronaviruses, the vulnerability of healthcare workers, coronaviruses on surface and in wastewater, diagnostics and cures, and measures to prevent spreading.

Decreased neck proprioception and postural stability after induced cervical flexor muscles fatigue.

OBJECTIVES: This study investigated the effect of cervical flexor muscles fatigue on neck proprioception and postural stability. METHODS: Forty-five male and female subjects were evaluated pre, immediate after induction of fatigue, and after recovery. Isometric neck flexor muscle endurance test (NET) was used for the induction of cervical flexor muscle fatigue. Cervical proprioception was assessed by cervical joint position error test (JPET) via overhead laser pointer while postural stability was assessed by using (a) biodex balance system measuring "Overall stability index (OSI), Anterior/ posterior (A/P) index and medial/ lateral (M/L) index", (b) multidirectional reach test. RESULTS: There was a significant decrease in cervical proprioception (cervical joint position error test) and postural stability (biodex balance system & multidirectional reach test) immediate post-induction of fatigue compared with both before induction of fatigue & after recovery from fatigue (p<0.001). CONCLUSION: Subjects suffering from cervical muscles fatigue are vulnerable to have a significant effect on neck proprioception and postural instability as it impaired the cervical proprioception sense & postural stability. Therefore, our study provides information for the clinicians and patients to avoid overload fatigue of the cervical muscles because it affects overall postural balance, neck proprioception & righting reaction.

Graphene-based nanomaterials for the removal of organic pollutants: Insights into linear versus nonlinear mathematical models.

The adsorption-desorption behavior of methylene blue, acid orange 7, bisphenol A, and phenol on the synthesized graphene-based nanomaterials were studied. For this purpose, adsorption experiments were conducted in a batch setup and different parameters such as contact time, pH, adsorbent dose concentration, and initial micropollutant concentration were considered. In addition, linear and nonlinear kinetic and isotherm models were evaluated. The nonlinear pseudo-second-order models (R2 > 0.98), Elovich kinetic models (R2 > 0.94), and Langmuir isotherm models (R2 > 0.98) best fitted the experimental data. Because of the high specific surface area and the type of oxygen functional groups, mechanochemically synthesized graphite oxide exhibited high adsorption capacities for methylene blue, acid orange 7, bisphenol A, and phenol, with a maximum uptake of 288, 232, 110, and 68 mg g-1, respectively. Furthermore, the total costs of applying the mechanochemically synthesized graphite oxide were estimated in the adsorption process, revealing that these nanomaterials offer better uptake values than porous carbon.

Aflibercept plus micropulse laser versus aflibercept monotherapy for diabetic macular edema: 1-year results of a randomized clinical trial.

PURPOSE: To evaluate the role of adjuvant micropulse laser with aflibercept injections in the management of treatment naive center involving DME, looking at decreased treatment burden and increased efficacy as outcomes after 1 year. METHODS: This was a prospective, single center, randomized trial that included 40 eyes (40 patients) with previously untreated center involved DME. Patients were randomly assigned to receive either aflibercept plus micropulse laser (group A) or aflibercept monotherapy (group B). RESULTS: Overall, 40 patients were included in the study; they were randomized into either group A (aflibercept + micropulse; 20 patients) or group B (aflibercept monotherapy; 20 patients). The mean number of injections after the loading dose was 4.5 ± 1.4 in group A and was 5.4 ± 1.7 in group B, and the difference between both groups was statistically significant (P = 0.029). CONCLUSION: Adding 577-nm micropulse laser to aflibercept is effective for treatment naïve DME and is associated with decreased number of injections.

Extracorporeal Membrane Oxygenation in Postcardiotomy Pediatric Patients-15 Years of Experience Outside Europe and North America.

BACKGROUND: The increasing complexity of congenital cardiac surgery has resulted in the increased use of extracorporeal membrane oxygenation (ECMO) support for children who cannot be weaned from cardiopulmonary bypass. The purpose of this research was to assess the mortality and morbidity in children requiring ECMO support after the repair of congenital heart defects (CHDs). METHODS: The hospital records of all patients with CHD who required ECMO after a cardiac surgical procedure between January 2001 and December 2016 were retrospectively reviewed. Various outcomes were reported and tested for any association with hospital death. RESULTS: A total of 113 children required ECMO for cardiopulmonary support after congenital cardiac surgery; 88 (77.9%) were placed on ECMO in the operating room. Median age of the patients was 3 months (range, 4 days-15 years) and median weight was 3.5 kg (range, 2.2-42.5). Forty-two (37.2%) survived to hospital discharge. In children with single-ventricle physiology, survival to discharge was 37.3% (19/51 patients) and for biventricular physiology, it was 37.1% (23/62 patients). Univariate analysis revealed number of days on ECMO support, renal failure, and stroke as risk factors for hospital mortality, while age and cross-clamp time were found to be statistically nonsignificant. CONCLUSION: Satisfactory results can be achieved in pediatric patients by using ECMO support for postoperative cardiac and pulmonary failure refractory to medical management. Prolonged ECMO support, renal failure, and stroke are risk of mortality.

Modified technique of internal limiting membrane staining in idiopathic macular hole surgery.

PURPOSE: To describe a new method of ILM staining with TB under perfluorocarbon in cases of full thickness idiopathic macular hole using the inverted ILM flap technique. METHODS: This study was a prospective interventional case series that included 42 eyes of 42 patients who had full thickness idiopathic macular hole with a minimum diameter more than 400 µm. Patients consecutively underwent vitrectomy with inverted ILM flap technique using the modified ILM staining method. RESULTS: Anatomic success was achieved in 40 patients (95.2%). The other two patients had flat-open macular holes with bare RPE (foveal defect of neurosensory retina). Among the 40 eyes with closed holes, 25 eyes were of the U-type closure (normal foveal contour) and 15 eyes were of the V-type closure (steep foveal contour). These 40 eyes remained closed during the 6 months follow-up period. CONCLUSION: The modified technique of ILM staining using TB under PFCL is safe and effective in cases of idiopathic macular hole combined with the inverted ILM flap technique.

Autonomous Robot-Guided Inspection System Based on Offline Programming and RGB-D Model.

Automatic optical inspection (AOI) is a control process for precisely evaluating the completeness and quality of manufactured products with the help of visual information. Automatic optical inspection systems include cameras, light sources, and objects; AOI requires expert operators and time-consuming setup processes. In this study, a novel autonomous industrial robot-guided inspection system was hypothesized and developed to expedite and ease inspection process development. The developed platform is an intuitive and interactive system that does not require a physical object to test or an industrial robot; this allows nonexpert operators to perform object inspection planning by only using scanned data. The proposed system comprises an offline programming (OLP) platform and three-dimensional/two-dimensional (3D/2D) vision module. A robot program generated from the OLP platform is mapped to an industrial manipulator to scan a 3D point-cloud model of an object by using a laser triangulation sensor. After a reconstructed 3D model is aligned with a computer-aided design model on a common coordinate system, the OLP platform allows users to efficiently fine-tune the required inspection positions on the basis of the rendered images. The arranged inspection positions can be directed to an industrial manipulator on a production line to capture real images by using the corresponding 2D camera/lens setup for AOI tasks. This innovative system can be implemented in smart factories, which are easily manageable from multiple locations. Workers can save scanned data when new inspection positions are included based on cloud data. The present system provides a new direction to cloud-based manufacturing industries and maximizes the flexibility and efficiency of the AOI setup process to increase productivity.

Optimization of Cadmium (CD(2+)) removal from aqueous solutions by novel biosorbent.

In this research, dead leaves of a common ornamental plant, Dracaena draca known also as dragon tree was used as a biosorbent for the removal of Cadmium (Cd(2+)) from aqueous solutions using a full 2(3) factorial experimental design. Three factors were investigated at two different levels, metal ion concentration (X = 10 and 100 ppm), hydrogen ion concentration (Ph = 2 and 7) and biomass dose (BD = 0.1 and 0.5g). Experiments were carried out in duplicates with 50 ml of Cd(2+) solutions at room temperature. When comparing observed values (experimental) with calculated values (model), they were set closely together that allowed suggesting a normal distribution where (R(2) = 0.9938). A characterization of the biosorbent was done by pHzpc and SEM-EDAX. Results also showed that the most significant effect for Cd(2+) biosorption was ascribed to (X). The interaction effects of (pH BD) and (X pH) were found to have significant influence on Cd(2+) removal efficiency. The highest Cd(2+) removal percentage attained by 79.60% at X = 10 ppm, pH = 7 and BD = 0.5g. The reusability of the biosorbent was tested in three desorption cycles and the regeneration efficiency was above 99.7%.

Insights into levofloxacin adsorption with machine learning models using nano-composite hydrochars.

Hydrothermal carbonization was applied to taro peel wastes to produce hydrochars using a facile and environmentally friendly process. Four different entities were prepared: hydrochar (TPh), phosphoric-activated hydrochar (P-TPh), and silver@hydrochars (Ag@TPh, Ag@P-TPh). The elemental compositions of the single and composite hydrochars were confirmed by EDX. Among the produced hydrochars, the morphology of the Ag@hydrochar composites demonstrated more wrinkled structure, and Ag nanoparticles decorated the surface. The optimal experimental conditions for levofloxacin adsorption were determined to be a contact time of 45 min, hydrochar dose of 0.15 g L-1, and pH of 7. The best adsorption performances were assigned to Ag@hydrochars. Two machine learning models were applied to predict the levofloxacin adsorption efficiency of the Ag@hydrochars. A central composite design (CCD) and a 3-10-1 artificial neural network (ANN) model were developed to estimate the removal performance of levofloxacin using Levenberg-Marquardt backpropagation algorithm based on correlation and error analysis of the adopted training functions. Furthermore, the ANN sensitivity analysis revealed the order of the relative importance variable as initial concentration> hydrochar dose> pH. The predicted values of the CCD and ANN models fitted the experimental results with R2> 0.989. Therefore, the applied models were effective in predicting levofloxacin removal under different operating conditions. This work provides an open option for the sustainable management of food industry wastes and the possibility of waste valorization to effective hydrochar composites to be applied in water treatment processes.

Sustainable fabrication of dimorphic plant derived ZnO nanoparticles and exploration of their biomedical and environmental potentialities.

Although, different plant species were utilized for the fabrication of polymorphic, hexagonal, spherical, and nanoflower ZnO NPs with various diameters, few studies succeeded in synthesizing small diameter ZnO nanorods from plant extract at ambient temperature. This work sought to pioneer the ZnO NPs fabrication from the aqueous extract of a Mediterranean salt marsh plant species Limoniastrum monopetalum (L.) Boiss. and assess the role of temperature in the fabrication process. Various techniques have been used to evaluate the quality and physicochemical characteristics of ZnO NPs. Ultraviolet-visible spectroscopy (UV-VIS) was used as the primary test for formation confirmation. TEM analysis confirmed the formation of two different shapes of ZnO NPs, nano-rods and near hexagonal NPs at varying reaction temperatures. The nano-rods were about 25.3 and 297.9 nm in diameter and in length, respectively while hexagonal NPs were about 29.3 nm. The UV-VIS absorption spectra of the two forms of ZnO NPs produced were 370 and 365 nm for nano-rods and hexagonal NPs, respectively. FT-IR analysis showed Zn-O stretching at 642 cm-1 and XRD confirmed the crystalline structure of the produced ZnO NPs. Thermogravimetric analysis; TGA was also used to confirm the thermal stability of ZnO NPs. The anti-tumor activities of the two prepared ZnO NPs forms were investigated by the MTT assay, which revealed an effective dose-dependent cytotoxic effect on A-431 cell lines. Both forms displayed considerable antioxidant potential, particularly the rod-shaped ZnO NPs, with an IC50 of 148.43 µg mL-1. The rod-shaped ZnO NPs were superior candidates for destroying skin cancer, with IC50 of 93.88 ± 1 µg mL-1 ZnO NPs. Thus, rod-shaped ZnO NPs are promising, highly biocompatible candidate for biological and biomedical applications. Furthermore, both shapes of phyto-synthesized NPs demonstrated effective antimicrobial activity against various pathogens. The outcomes highlight the potential of phyto-synthesized ZnO NPs as an eco-friendly alternative for water and wastewater disinfection.

Vertical alveolar bone augmentation of atrophied posterior mandibular regions with simultaneous dental implant placement using allogeneic bone rings vs autogenous bone rings: a randomized controlled clinical trial.

OBJECTIVE: Ideal implant placement in atrophied posterior mandibular regions is challenging due to surgical difficulties and anatomical limitations. This study aimed to evaluate the use of allogeneic bone rings for vertical augmentation of atrophied posterior mandibular regions with simultaneous implants compared to autogenous bone rings, while avoiding donor site morbidity. METHOD AND MATERIALS: A total of 24 vertically atrophied posterior mandibular segments (in 14 patients) were equally randomized into a study group in which mineralized freeze-dried allogeneic bone rings were used, and a control group in which autogenous bone rings with prepared implant osteotomies were harvested from the chin and used. All augmentation sites were prepared before inserting the bone rings. Implants were simultaneously inserted, fixing the bone rings into the native bone. All patients were clinically assessed after 1 week, 2 weeks, and 1 month. Crestal bone level was radiographically assessed after 1 week, 6 months, and 3 months of prosthetic loading. RESULTS: None of the 24 bone rings showed signs of implant or graft failure. There was no significant difference in the crestal bone level between the groups. CONCLUSION: Allogeneic bone rings can be a viable alternative to autogenous bone rings in augmenting the posterior aspect of the mandible, mitigating the concerns associated with donor site complications.

Corneal densitometry changes after femtosecond laser-assisted intracorneal ring segments implantation in keratoconus.

Background: Intrastromal corneal ring segments are commonly implanted in the corneas of eyes with mild-to-moderate keratoconus; however, changes in corneal densitometry (CD) after implantation are a matter of debate in the current literature. We evaluated the changes in CD 1 and 3 months after femtosecond laser-assisted Keraring implantation. Methods: This retrospective, non-comparative, multicenter, case series study included patients with keratoconus who underwent femtosecond laser-assisted implantation of double segments with 90° and 160° arc lengths or two 160° arc length Keraring segments. Demographic and baseline clinical ophthalmic data were recorded. Corneal topography and tomography data acquired using a Pentacam HR Scheimpflug tomography system (Pentacam High Resolution; Oculus, Wetzlar, Germany) with a best-fit sphere were used as a reference surface. Using the Pentacam HR, CD measurements were acquired over a corneal area of 12 mm in total and at four concentric zones (0-2, 2-6, 6-10, and 10-12 mm) of three corneal stromal depths: 120 µm of the anterior corneal stromal layer, 60 µm of the posterior corneal stromal layer, and the central layer of stroma lying between these two layers. Results: We included 40 eyes of 40 patients, including 8 (20%) male and 32 (80%) female individuals, with a mean (standard deviation) age of 21.0 (6.4) years. We observed a significant improvement in the topographic values of steep keratometry (K), flat K, maximum K, and corneal astigmatism (all P < 0.05), but not in the mean K, thinnest corneal pachymetry, corneal thickness at the apex, back elevation, or front elevation (all P > 0.05). The mean total anterior, central, and posterior CD differed significantly among the time points, with a significant increase from the preoperative to the 1-month and 3-month postoperative visits (all P < 0.05) and no difference between those of the 1-month and 3-month postoperative visits (all P > 0.05). The mean CD for the anterior layer in the central, paracentral, and mid-peripheral zones, and the central layer in all four zones, differed significantly among time points, with a significant increase from the preoperative to the 1-month and 3-month postoperative visits (all P < 0.05), which remained unchanged from the 1-month to the 3-month postoperative visit (all P < 0.05), except for the central 2-6-mm zone, which decreased significantly from the 1-month to the 3-month postoperative visit (P < 0.001). The CD of the central 10-12-mm zone did not differ significantly in each pairwise comparison (all P > 0.05). In contrast, CD for the posterior layer in the paracentral zone decreased significantly from the preoperative to the 1-month and 3-month postoperative visits but increased, to a lesser extent, from the 1-month to the 3-month postoperative visit (all P < 0.05). Conclusions: Femtosecond laser-assisted Keraring implantation significantly changes CD, with improvement in most topography parameters. Further longitudinal studies with larger sample sizes are required to verify these preliminary findings.

Nanofiltration Membranes for the Removal of Heavy Metals from Aqueous Solutions: Preparations and Applications.

Water shortages are one of the problems caused by global industrialization, with most wastewater discharged without proper treatment, leading to contamination and limited clean water supply. Therefore, it is important to identify alternative water sources because many concerns are directed toward sustainable water treatment processes. Nanofiltration membrane technology is a membrane integrated with nanoscale particle size and is a superior technique for heavy metal removal in the treatment of polluted water. The fabrication of nanofiltration membranes involves phase inversion and interfacial polymerization. This review provides a comprehensive outline of how nanoparticles can effectively enhance the fabrication, separation potential, and efficiency of NF membranes. Nanoparticles take the form of nanofillers, nanoembedded membranes, and nanocomposites to give multiple approaches to the enhancement of the NF membrane's performance. This could significantly improve selectivity, fouling resistance, water flux, porosity, roughness, and rejection. Nanofillers can form nanoembedded membranes and thin films through various processes such as in situ polymerization, layer-by-layer assembly, blending, coating, and embedding. We discussed the operational conditions, such as pH, temperature, concentration of the feed solution, and pressure. The mitigation strategies for fouling resistance are also highlighted. Recent developments in commercial nanofiltration membranes have also been highlighted.