Detalhe da pesquisa
1.
Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis.
N Engl J Med
; 384(12): 1101-1112, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33761207
2.
The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans.
Drug Metab Dispos
; 50(8): 1106-1118, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35701182
3.
Population pharmacokinetic-pharmacodynamic modelling of platelet time-courses following administration of abrocitinib.
Br J Clin Pharmacol
; 88(8): 3856-3871, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35342978
4.
Abuse Potential Study of ALO-02 (Extended-Release Oxycodone Surrounding Sequestered Naltrexone) Compared with Immediate-Release Oxycodone Administered Orally to Nondependent Recreational Opioid Users.
Pain Med
; 18(6): 1077-1088, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27550954
5.
Intravenous abuse potential study of oxycodone alone or in combination with naltrexone in nondependent recreational opioid users.
Am J Drug Alcohol Abuse
; 42(5): 539-549, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27211522
6.
Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals.
Eur J Drug Metab Pharmacokinet
; 49(3): 367-381, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38554232
7.
Population Pharmacokinetic and Pharmacodynamic Modeling of Fesoterodine in Pediatric Patients with Neurogenic Detrusor Overactivity.
Eur J Drug Metab Pharmacokinet
; 48(3): 257-269, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36892754
8.
Fesoterodine treatment of pediatric patients with neurogenic detrusor overactivity: A 24-week, randomized, open-label, phase 3 study.
J Pediatr Urol
; 19(2): 175.e1-175.e10, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36504158
9.
Population Pharmacokinetics of Abrocitinib in Healthy Individuals and Patients with Psoriasis or Atopic Dermatitis.
Clin Pharmacokinet
; 61(5): 709-723, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35061234
10.
Population Pharmacokinetic/Pharmacodynamic Modeling of the Effect of Abrocitinib on QT Intervals in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 11(9): 1036-1045, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35532896
11.
Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.
J Clin Pharmacol
; 62(4): 505-519, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34637151
12.
Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals.
Eur J Drug Metab Pharmacokinet
; 47(3): 419-429, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35226304
13.
Evaluation of the Effect of Abrocitinib on Drug Transporters by Integrated Use of Probe Drugs and Endogenous Biomarkers.
Clin Pharmacol Ther
; 112(3): 665-675, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35344588
14.
Comparing abrocitinib and dupilumab in the treatment of atopic dermatitis: a plain language summary.
Immunotherapy
; 14(1): 5-14, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34775830
15.
Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers.
Br J Clin Pharmacol
; 72(2): 226-34, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21352267
16.
Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects.
Br J Clin Pharmacol
; 72(2): 263-9, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21545485
17.
Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers.
Br J Clin Pharmacol
; 72(2): 257-62, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21496065
18.
A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
Br J Clin Pharmacol
; 72(2): 235-46, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21392072
19.
Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.
J Clin Pharmacol
; 61(10): 1311-1323, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33749838
20.
Effect of the CYP2D6*10 genotype on tolterodine pharmacokinetics.
Drug Metab Dispos
; 38(9): 1456-63, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20530222