Detalhe da pesquisa
1.
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 23(19): 5442-7, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23953070
2.
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.
ACS Med Chem Lett
; 12(6): 969-975, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141082
3.
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(19): 5864-8, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20732813
4.
Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.
Bioorg Med Chem Lett
; 19(1): 96-9, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19010676
5.
Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.
ACS Med Chem Lett
; 10(3): 300-305, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891130
6.
Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
J Med Chem
; 50(6): 1365-79, 2007 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17315987
7.
Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.
J Med Chem
; 49(26): 7596-9, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181141
8.
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
J Med Chem
; 49(24): 6946-9, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125246
9.
Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.
J Med Chem
; 47(10): 2587-98, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15115400
10.
Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.
Eur J Pharmacol
; 651(1-3): 9-17, 2011 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21044623
11.
Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.
J Med Chem
; 53(3): 1270-80, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047280
12.
Sulfonation with Inversion by Mitsunobu Reaction: An Improvement on the Original Conditions.
J Org Chem
; 61(22): 7955-7958, 1996 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667761
13.
Novel 1,4-homofragmentation via an alpha-lactone.
J Org Chem
; 71(22): 8647-50, 2006 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064050
14.
A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes.
Bioorg Med Chem Lett
; 15(11): 2749-51, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15878269
15.
One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.
J Org Chem
; 69(1): 188-91, 2004 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14703396
16.
Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.
Bioorg Med Chem Lett
; 12(1): 45-9, 2002 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11738570