Detalhe da pesquisa
1.
Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
Xenobiotica
; 51(2): 177-193, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902324
2.
In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.
Br J Clin Pharmacol
; 83(5): 1082-1096, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27862160
3.
Rosuvastatin Myotoxicity After Starting Canagliflozin Treatment.
Ann Intern Med
; 174(3): 431-432, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33721528
4.
Successful integration of nonclinical and clinical findings in interpreting the clinical relevance of rodent neoplasia with a new chemical entity.
Toxicol Pathol
; 43(1): 48-56, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398756
5.
Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on the pharmacokinetics of oral contraceptives, warfarin, and digoxin in healthy participants.
Int J Clin Pharmacol Ther
; 53(1): 41-53, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25345427
6.
Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants.
Int J Clin Pharmacol Ther
; 53(2): 115-28, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25407255
7.
Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.
Drug Metab Dispos
; 42(5): 903-16, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24568888
8.
Niraparib Shows Superior Tissue Distribution and Efficacy in a Prostate Cancer Bone Metastasis Model Compared with Other PARP Inhibitors.
Mol Cancer Ther
; 21(7): 1115-1124, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35499386
9.
Prediction of the drug-drug interaction potential of the α1-acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 1107-1118, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34273250
10.
Niraparib with androgen receptor-axis-targeted therapy in patients with metastatic castration-resistant prostate cancer: safety and pharmacokinetic results from a phase 1b study (BEDIVERE).
Cancer Chemother Pharmacol
; 88(1): 25-37, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33754187
11.
Effect of Fluconazole and Itraconazole on the Pharmacokinetics of Erdafitinib in Healthy Adults: A Randomized, Open-Label, Drug-Drug Interaction Study.
Eur J Drug Metab Pharmacokinet
; 45(1): 101-111, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31673875
12.
Tissue distribution and depletion kinetics of bortezomib and bortezomib-related radioactivity in male rats after single and repeated intravenous injection of 14 C-bortezomib.
Cancer Chemother Pharmacol
; 60(6): 777-87, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17285316
13.
Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study.
Chem Biol Interact
; 277: 85-90, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28916336
14.
Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study.
J Clin Pharmacol
; 45(4): 453-60, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15778426
15.
Cell-based models to study hepatic drug metabolism and enzyme induction in humans.
Expert Opin Drug Metab Toxicol
; 1(1): 75-90, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16922654
16.
Absolute oral bioavailability and pharmacokinetics of canagliflozin: A microdose study in healthy participants.
Clin Pharmacol Drug Dev
; 4(4): 295-304, 2015 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27136910
17.
In vitro metabolism of canagliflozin in human liver, kidney, intestine microsomes, and recombinant uridine diphosphate glucuronosyltransferases (UGT) and the effect of genetic variability of UGT enzymes on the pharmacokinetics of canagliflozin in humans.
J Clin Pharmacol
; 55(9): 1061-72, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25827774
18.
Effect of canagliflozin on the pharmacokinetics of glyburide, metformin, and simvastatin in healthy participants.
Clin Pharmacol Drug Dev
; 4(3): 226-36, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-27140803
19.
Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones.
J Med Chem
; 45(18): 3953-62, 2002 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12190317
20.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory cancer patients in a phase I dose escalation study.
J Clin Pharmacol
; 44(7): 723-36, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15199077