Detalhe da pesquisa
1.
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Nature
; 523(7559): 183-188, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26131937
2.
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.
Blood
; 126(6): 779-89, 2015 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26002965
3.
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Bioorg Med Chem Lett
; 23(1): 360-5, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23168019
4.
1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.
Bioorg Med Chem
; 19(21): 6356-74, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21955454
5.
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions.
Microvasc Res
; 77(2): 78-86, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18805433
6.
Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1.
J Med Chem
; 61(2): 492-503, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28358507
7.
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J Med Chem
; 61(2): 535-542, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28425720
8.
Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition.
Cancer Res
; 63(23): 8073-8, 2003 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14678955
9.
A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins.
Cancer Res
; 63(3): 593-9, 2003 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12566301
10.
Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Oncol Res
; 14(2): 75-82, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14649541
11.
Direct Synthesis of [alpha-[(tert-Butoxycarbonyl)amino]alkyl]- boronates from (alpha-Haloalkyl)boronates.
J Org Chem
; 61(22): 7951-7954, 1996 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667760
12.
Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells.
Pancreas
; 38(1): 78-84, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19117086
13.
Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.
J Med Chem
; 52(6): 1522-4, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19256507
14.
Alpha-fluoro-substituted thalidomide analogues.
Bioorg Med Chem Lett
; 13(20): 3415-7, 2003 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-14505639
15.
Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs.
J Pharmacol Exp Ther
; 305(3): 1222-32, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12649301