Detalhe da pesquisa
1.
Esmethadone-HCl (REL-1017): a promising rapid antidepressant.
Eur Arch Psychiatry Clin Neurosci
; 273(7): 1463-1476, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36890259
2.
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling.
Int J Mol Sci
; 23(20)2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36293063
3.
Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone'.
Mol Psychiatry
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38806691
4.
Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies.
J Clin Psychopharmacol
; 39(3): 226-237, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30939592
5.
REL-1017 (Esmethadone) May Rapidly Reduce Dissociative Symptoms in Adults With Major Depressive Disorder Unresponsive to Standard Antidepressants: A Report of 2 Cases.
J Clin Psychopharmacol
; 42(5): 503-506, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35943402
6.
Sex-dependent effects of the uncompetitive N-methyl-D-aspartate receptor antagonist REL-1017 in G93A-SOD1 amyotrophic lateral sclerosis mice.
Front Neurol
; 15: 1384829, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38765264
7.
Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder.
Prim Care Companion CNS Disord
; 25(1)2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36821775
8.
Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.
Drugs R D
; 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010591
9.
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Transl Psychiatry
; 13(1): 192, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286536
10.
REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats.
Front Pharmacol
; 13: 863959, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35571103
11.
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin.
Pharmaceuticals (Basel)
; 15(7)2022 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35890179
12.
REL-1017 (esmethadone; D-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats.
Sci Rep
; 12(1): 11389, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35794162
13.
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors.
Pharmaceuticals (Basel)
; 15(8)2022 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36015145
14.
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.
Am J Psychiatry
; 179(2): 122-131, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34933568
15.
REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study.
Front Pharmacol
; 12: 671859, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33995104
16.
Comment on "Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status".
CNS Drugs
; 36(2): 203-204, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35015265
17.
Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain.
Pain
; 96(3): 325-328, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11973005
18.
QTc interval prolongation associated with intravenous methadone.
Pain
; 105(3): 499-506, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14527710
19.
Central pain in cancer patients.
J Pain
; 4(6): 351-4, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-14622693
20.
Pain assessment in elderly patients with severe dementia.
J Pain Symptom Manage
; 25(1): 48-52, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12565188