Detalhe da pesquisa
1.
Domain analysis of PNKP-XRCC1 interactions: Influence of genetic variants of XRCC1.
J Biol Chem
; 294(2): 520-530, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30446622
2.
Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.
Nucleic Acids Res
; 45(10): 6238-6251, 2017 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28453785
3.
The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.
J Biol Chem
; 292(39): 16024-16031, 2017 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28821613
4.
Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.
Trends Biochem Sci
; 36(5): 262-71, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353781
5.
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Nucleic Acids Res
; 39(21): 9224-37, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21824916
6.
XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.
J Biol Chem
; 286(37): 32638-50, 2011 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21775435
7.
Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1.
Nucleic Acids Res
; 38(2): 510-21, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19910369
8.
Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains.
Front Oncol
; 12: 819172, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35372043
9.
Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor.
Sci Rep
; 12(1): 5386, 2022 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35354845
10.
Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.
J Biol Chem
; 285(48): 37619-29, 2010 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20852255
11.
Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.
J Biol Chem
; 285(4): 2351-60, 2010 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19940137
12.
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.
J Control Release
; 334: 335-352, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33933518
13.
Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.
Eur J Med Chem
; 204: 112658, 2020 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738410
14.
Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.
J Med Chem
; 62(17): 7684-7696, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31369707
15.
Hydrodynamic and spectroscopic studies of substrate binding to human recombinant deoxycytidine kinase.
Nucleosides Nucleotides Nucleic Acids
; 22(2): 175-92, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12744604
16.
XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates.
J Biol Chem
; 282(38): 28004-13, 2007 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17650498
17.
Fluorescence energy transfer studies of human deoxycytidine kinase: role of cysteine 185 in the conformational changes that occur upon substrate binding.
Biochemistry
; 45(11): 3534-41, 2006 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16533034
18.
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol Cell
; 17(5): 657-70, 2005 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15749016
19.
Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex.
Biochemistry
; 42(41): 12077-84, 2003 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-14556639
20.
Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA.
Biochemistry
; 43(51): 16505-14, 2004 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15610045