A non local model for cell migration in response to mechanical stimuli.

Cell migration is one of the most studied phenomena in biology since it plays a fundamental role in many physiological and pathological processes such as morphogenesis, wound healing and tumorigenesis. In recent years, researchers have performed experiments showing that cells can migrate in response to mechanical stimuli of the substrate they adhere to. Motion towards regions of the substrate with higher stiffness is called durotaxis, while motion guided by the stress or the deformation of the substrate itself is called tensotaxis. Unlike chemotaxis (i.e. the motion in response to a chemical stimulus), these migratory processes are not yet fully understood from a biological point of view. In this respect, we present a mathematical model of single-cell migration in response to mechanical stimuli, in order to simulate these two processes. Specifically, the cell moves by changing its direction of polarization and its motility according to material properties of the substrate (e.g., stiffness) or in response to proper scalar measures of the substrate strain or stress. The equations of motion of the cell are non-local integro-differential equations, with the addition of a stochastic term to account for random Brownian motion. The mechanical stimulus to be integrated in the equations of motion is defined according to experimental measurements found in literature, in the case of durotaxis. Conversely, in the case of tensotaxis, substrate strain and stress are given by the solution of the mechanical problem, assuming that the extracellular matrix behaves as a hyperelastic Yeoh's solid. In both cases, the proposed model is validated through numerical simulations that qualitatively reproduce different experimental scenarios.

The N -Link Swimmer in Three Dimensions: Controllability and Optimality Results.

The controllability of a fully three-dimensional N -link swimmer is studied. After deriving the equations of motion in a low Reynolds number fluid by means of Resistive Force Theory, the controllability of the minimal 2-link swimmer is tackled using techniques from Geometric Control Theory. The shape of the 2-link swimmer is described by two angle parameters. It is shown that the associated vector fields that govern the dynamics generate, via taking their Lie brackets, all eight linearly independent directions in the combined configuration and shape space, leading to controllability; the swimmer can move from any starting configuration and shape to any target configuration and shape by operating on the two shape variables. The result is subsequently extended to the N -link swimmer. Finally, the minimal time optimal control problem and the minimization of the power expended are addressed and a qualitative description of the optimal strategies is provided.