Detalhe da pesquisa
1.
Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori.
Biochem Cell Biol
; 102(3): 226-237, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38377487
2.
Squaramide Formation for DNA-Encoded Library Synthesis.
Bioconjug Chem
; 2024 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38874002
3.
Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.
Bioinformatics
; 35(14): i464-i473, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31510684
4.
Diagnostic Accuracy of Procalcitonin for Early Aspiration Pneumonia in Critically Ill Patients with Coma: A Prospective Study.
Neurocrit Care
; 30(2): 440-448, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30267280
5.
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.
Blood
; 127(24): 3054-61, 2016 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27034432
6.
Identification of small molecules that support human leukemia stem cell activity ex vivo.
Nat Methods
; 11(4): 436-42, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24562423
7.
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Nat Chem Biol
; 10(2): 156-163, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24316736
8.
Medicinal Chemistry and NMR Driven Discovery of Novel UDP-glucuronosyltransferase 1A Inhibitors That Overcome Therapeutic Resistance in Cells.
J Mol Biol
; 436(2): 168378, 2024 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38043731
9.
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
Sci Adv
; 10(12): eadl4018, 2024 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38517966
10.
Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen.
ACS Chem Biol
; 18(5): 1039-1046, 2023 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37097827
11.
HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.
Blood Adv
; 6(16): 4793-4806, 2022 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35797243
12.
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.
Blood Adv
; 6(2): 509-514, 2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34731885
13.
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
J Med Chem
; 65(13): 8843-8854, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35729784
14.
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
Nat Commun
; 13(1): 2801, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35589701
15.
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
Cell Stem Cell
; 28(1): 48-62.e6, 2021 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33417871
16.
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.
Sci Adv
; 7(44): eabi5797, 2021 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34705497
17.
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Nat Commun
; 12(1): 4688, 2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344896
18.
Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
ACS Med Chem Lett
; 11(11): 2261-2267, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214838
19.
Genetic characterization of ABT-199 sensitivity in human AML.
Leukemia
; 34(1): 63-74, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31300747
20.
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.
Lancet Haematol
; 7(2): e134-e145, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31704264