Detalhe da pesquisa
1.
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Bioorg Med Chem Lett
; 23(5): 1212-6, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375793
2.
Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.
Org Biomol Chem
; 9(3): 881-91, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21127791
3.
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Nature
; 434(7035): 917-21, 2005 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15829967
4.
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Proc Natl Acad Sci U S A
; 105(44): 17079-84, 2008 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18971340
5.
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Nat Commun
; 12(1): 3636, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34140467
6.
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR.
Bioorg Med Chem Lett
; 19(20): 5898-901, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19733066
7.
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
Clin Cancer Res
; 14(12): 3916-25, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559613
8.
Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase.
Bioorg Med Chem Lett
; 18(14): 3942-5, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18579376
9.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
J Med Chem
; 50(8): 1958-72, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371003
10.
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
Cancer Res
; 65(22): 10145-8, 2005 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16287996
11.
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
Cancer Res
; 64(24): 9152-9, 2004 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15604286
12.
The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.
Cancer Res
; 76(20): 6084-6094, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27550455
13.
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
Cancer Biol Ther
; 4(9): 934-6, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16251802
14.
A FlashPlate assay for the identification of PARP-1 inhibitors.
J Biomol Screen
; 8(3): 347-52, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12857389
15.
Deubiquitylating enzymes and DNA damage response pathways.
Cell Biochem Biophys
; 67(1): 25-43, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23712866
16.
Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer.
Mol Cancer Ther
; 12(6): 959-67, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23512991
17.
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.
Cancer Discov
; 3(1): 68-81, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103855
18.
Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.
Mol Cancer Ther
; 11(8): 1789-98, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22576130
19.
Progress in the function and regulation of ADP-Ribosylation.
Sci Signal
; 4(174): mr5, 2011 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21610250
20.
5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).
J Med Chem
; 54(7): 2049-59, 2011 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21417348