Detalhe da pesquisa
1.
Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature
; 558(7710): E1, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29769713
2.
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature
; 550(7674): 128-132, 2017 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28953875
3.
In-vitro modeling of intravenous drug precipitation by the optical spatial precipitation analyzer (OSPREY).
Int J Pharm
; 636: 122842, 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36925024
4.
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Commun Med (Lond)
; 3(1): 154, 2023 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37880389
5.
Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Inflamm Res
; 60(7): 683-93, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21394563
6.
In vitro studies on a class of quinoline containing histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(11): 3295-300, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457525
7.
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
J Pharmacol Toxicol Methods
; 103: 106871, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32360993
8.
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
J Med Chem
; 50(13): 2990-3003, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17523610
9.
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
J Med Chem
; 50(7): 1584-97, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17343372
10.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
11.
The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.
J Pharmacol Toxicol Methods
; 56(1): 11-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350293
12.
Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.
Biochem Pharmacol
; 71(3): 278-86, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16325148
13.
The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
J Pharmacol Toxicol Methods
; 50(3): 187-99, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15519905
14.
Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.
Life Sci
; 90(15-16): 607-11, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22406079
15.
Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds.
J Pharmacol Toxicol Methods
; 64(1): 68-73, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21440075
16.
Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.
Curr Drug Saf
; 6(5): 277-84, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22424534
17.
A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current.
Biochem Pharmacol
; 80(7): 1000-6, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20599796
18.
Electrophysiologic characterization of a novel hERG channel activator.
Biochem Pharmacol
; 77(8): 1383-90, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19426677
19.
Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.
CNS Neurosci Ther
; 14(1): 65-82, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18482100
20.
Functional consequences of methionine oxidation of hERG potassium channels.
Biochem Pharmacol
; 74(5): 702-11, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17624316