[Deliberate self-harm and psychoactive substance use in colombian school adolescents]. / Autolesiones deliberadas y consumo de sustancias psicoactivas en adolescentes escolarizados de Colombia 2016.

BACKGROUND: Deliberate self-harm and the consumption of psy- choactive substances are important public health problems among adolescents. AIM: To determine the association of deliberate self-harm with the consumption of psychoactive substances, in school adolescents in Colombia. MATERIAL AND METHODS: A survey about deliberate self harm and psychoactive substance use during the last 12 months was answered by 80 018 adolescents aged between 12 and 18 years. RESULTS: The prevalence of deliberate self-harm in the last 12 months was 14.1%. The use of psychoactive drugs was associated with deliberate self-harm. The greatest association was observed with the use of non-prescription tranquilizers (Odds ratio 4.05 95% confidence intervals 3.42-4.81). CONCLUSIONS: We observed an association between deliberate self-harm and the consumption of different psychoactive substances.

Analysis of reporting completeness in exercise cancer trials: a systematic review.

BACKGROUND: Exercise is an effective therapeutic intervention for cancer survivors. Concerns about the completeness of reporting of exercise interventions have been raised in the literature, but without any formal analysis. This study aimed to evaluate the completeness of reporting of exercise interventions for cancer survivors in a large sample of randomized clinical trials (RCTs). METHODS: We developed a pre-defined protocol. We searched MEDLINE, EMBASE, and CENTRAL for exercise trials in oncology between 2010 and 2017. Pairs of independent researchers screened the records, extracted study characteristics, and assessed 16 items on the TIDieR checklist (i.e., the 12 items, with item 5 divided into two and item 8 divided into four). For each of these items, the percentage of interventions in the included studies that reported the item was calculated. RESULTS: We included 131 RCTs reporting 138 interventions in the analysis. Breast cancer was the most common type of cancer (69, 50%), and aerobic exercise was the most studied exercise modality (43, 30%) followed by combined aerobic and resistance training (40, 28%). Completeness of reporting ranged from 42 to 96% among the TIDieR items; none of the items was fully reported. 'Intervention length' was the most reported item across interventions (133, 96%), followed by 'rationale' (131, 95%), whereas 'provider' (58, 42%) and 'how well (planned)' (63, 46%) were the two least reported items. Half of the TIDieR items were completely reported in 50 to 70% of the interventions, and only four items were reported in more than 80% of the interventions (Items 2 and 8a to c). The seven items deemed to be core for replication (Items 3 to 9) exhibited a mean reporting of 71%, ranging from 42 to 96%. CONCLUSION: Exercise training interventions for cancer survivors are incompletely reported across RCTs published between 2010 and 2017. The reporting of information about the provider, materials, and modifications require urgent improvements. Stronger reporting will enhance usability of trial reports by both healthcare providers and survivors, and will help to reduce research waste.

[Marijuana consumption among Colombian adolescents]. / Prevalencia de vida y factores asociados al consumo de marihuana en estudiantes escolarizados de Pamplona-Colombia, durante el primer período de 2015: estudio Emtamplona.

BACKGROUND: Marijuana consumption is a public health problem. AIM: To determine the life time prevalence of marijuana use among Colombian adolescents and the factors associated with its consumption. MATERIAL AND METHODS: Secondary analysis of data from a study aimed to determine the prevalence of smoking. A self-administered and anonymous questionnaire was answered by 814 adolescents aged 14 ± 2 years (439 women). RESULTS: Ten percent of respondents consumed marijuana at least once in their life. A logistic regression analysis showed that professing a non-christian religion, being smoker and having an age over 12 years, was associated with marijuana consumption. CONCLUSIONS: There is a high frequency of marijuana use among these adolescents.

Using LMS tables to determine waist circumference and waist-to-height ratios in Colombian children and adolescents: the FUPRECOL study.

BACKGROUND: Waist circumference (WC) and waist-to-height ratio (WHtR) are often used as indices predictive of central obesity. The aims of this study were: 1) to obtain smoothed centile charts and LMS tables for WC and WHtR among Colombian children and adolescents; 2) to evaluate the utility of these parameters as predictors of overweight and obesity. METHOD: A cross-sectional study was conducted of a sample population of 7954 healthy Colombian schoolchildren [3460 boys and 4494 girls, mean age 12.8 (±2.3) years]. Weight, height, body mass index (BMI), WC and WHtR were measured, and percentiles were calculated using the LMS method (Box-Cox, median and coefficient of variation). Appropriate cut-off points of WC and WHtR for overweight and obesity, according to International Obesity Task Force definitions, were selected using receiver operating characteristic (ROC) analysis. The discriminating power of WC and WHtR is expressed as area under the curve (AUC). RESULTS: Reference values for WC and WHtR are presented. Mean WC increased and WHtR decreased with age for both genders. A moderate positive correlation was observed between WC and BMI (r = 0.756, P < 0.01) and between WHtR and BMI (r = 0.604, P < 0.01). ROC analysis revealed strong discrimination power in the identification of overweight and obesity for both measures in our sample population. Overall, WHtR was a slightly better predictor of overweight/obesity (AUC 95% CI 0.868-0.916) than WC (AUC 95% CI 0.862-0.904). CONCLUSION: This paper presents the first sex and age-specific WC and WHtR percentiles for Colombian children and adolescents aged 9.0-17.9 years. The LMS tables obtained, based on Colombian reference data, can be used as quantitative tools for the study of obesity and its comorbidities.

[Prevalence of smoking among Colombian adolescents]. / Prevalencia y factores asociados al consumo de cigarrillo tradicional, en adolescentes escolarizados.

BACKGROUND: Cigarette smoking is considered the most important preventable public health problem in developed countries, especially among adolescents. AIM: To determine the prevalence of cigarette smoking and associated factors in high school adolescents, from a Colombian city. MATERIAL AND METHODS: The self-administered global tobacco youth survey (GTYS) was answered by 831 teenagers aged 14 ± 2 years (54% females). For data analysis, proportions were calculated; for associations, binary and multivariable logistic regression was applied. RESULTS: Fourteen percent of respondents declared that they had consumed at least one cigarette during the last 30 days. The life-time prevalence of tobacco use was 27.1%. Being older than thirteen years old, father’s academic level and having a smoker mother were factors associated with smoking. CONCLUSIONS: The prevalence of smoking in these adolescents was high. Age over 13 years and a smoking mother were associated with the cigarette smoking.

Vitamin B12 concentrations in pregnant Colombian women: analysis of nationwide data 2010.

BACKGROUND: Vitamin B12 deficiency is associated with many adverse health outcomes and is highly prevalent worldwide. The present study assesses the prevalence and socio-demographic factors associated with vitamin B12 deficiency in a representative sample of pregnant women in Colombia. METHOD: We used data from the cross-sectional, nationally representative survey (ENSIN, 2010). A total of 1.781, (13-49 years old) pregnant women were enrolled. Serum Vitamin B12 a concentration was determined by chemiluminescence and sociodemographic date was assessed by computer-assisted personal interview technology. Multivariate analyses using unordered multinomial logistic regression models were conducted in the main analysis. RESULTS: Vitamin B12 concentrations ranged from 45 to 1000 pg/mL (mean 299.2 pg/mL, 95% CI 290.6 to 303.7 pg/mL). A total of 18.6% of pregnant women had vitamin B12 concentrations below 200 pg/mL and 41.3% had concentrations between 200 and 300 pg/mL. Being of indigenous ethnicity, living in the east and living in a rural area showed the lowest mean values (273.2 pg/mL, 270.8 pg/mL and 290.1 pg/mL, respectively). The multivariate logistic regression shows that pregnant women belonging to the indigenous ethnic group OR 2.2, (95% CI 1.1 to 4.3), living in the pacific region (west) OR 4.4, (95% CI 2.8 to 6.9), or national territories (south) OR 2.3, (95% CI 1.4 to 3.7) were associated with a higher probability of serum vitamin B12 deficiency. CONCLUSION: The prevalence of vitamin B12 deficiency in Colombian pregnant women is substantial. Factors associated with depletion among pregnant women should be considered for future interventions in countries experiencing nutritional transition.

School refusal profiles maintained by negative reinforcement and their relationship with self-perceived health.

Health alterations and school refusal behavior may significantly affect student evolution in all areas of student lives. The objective of this study was to use latent profile analysis to identify school refusal profiles sustained by negative reinforcement and to determine their relationship with distinct self-perceived health variables (Satisfaction, Well-being, Resilience, Performance, and Risk-Taking). The School Refusal Assessment Scale-Revised (SRAS-R) and the Child Health and Illness Profile (CHIP-CE/CRF) were administered to 737 students (60.9% male) aged between 8 and 10 (M = 8.76, SD = 0.74). Three profiles of school refusal maintained by negative reinforcement were obtained: no risk, moderate risk, and high risk. It was confirmed that school refusal through negative reinforcement correlates negatively with health dimensions, also finding that a higher risk profile for school refusal is associated with lower levels of self-perceived health. Similarly, it was determined that the high-risk profile is the most maladaptive, with significantly lower data in four of the five self-perceived health dimensions that were evaluated. In conclusion, remaining in situations with no or moderate risk of school refusal due to negative reinforcement encourages higher levels of self-perceived health, while being at high risk of school refusal due to negative reinforcement is associated with worse self-perceived health.

Estimating mobility of tourists. New Twitter-based procedure.

Twitter has been actively researched as a human mobility proxy. Tweets can contain two classes of geographical metadata: the location from which a tweet was published, and the place where the tweet is estimated to have been published. Nevertheless, Twitter also presents tweets without any geographical metadata when querying for tweets on a specific location. This study presents a methodology which includes an algorithm for estimating the geographical coordinates to tweets for which Twitter doesn't assign any. Our objective is to determine the origin and the route that a tourist followed, even if Twitter doesn't return geographically identified data. This is carried out through geographical searches of tweets inside a defined area. Once a tweet is found inside an area, but its metadata contains no explicit geographical coordinates, its coordinates are estimated by iteratively performing geographical searches, with a decreasing geographical searching radius. This algorithm was tested in two touristic villages of Madrid (Spain) and a major city in Canada. A set of tweets without geographical coordinates in these areas were found and processed. The coordinates of a subset of them were successfully estimated.

Proof of concept of the potential of a machine learning algorithm to extract new information from conventional SARS-CoV-2 rRT-PCR results.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been and remains one of the major challenges modern society has faced thus far. Over the past few months, large amounts of information have been collected that are only now beginning to be assimilated. In the present work, the existence of residual information in the massive numbers of rRT-PCRs that tested positive out of the almost half a million tests that were performed during the pandemic is investigated. This residual information is believed to be highly related to a pattern in the number of cycles that are necessary to detect positive samples as such. Thus, a database of more than 20,000 positive samples was collected, and two supervised classification algorithms (a support vector machine and a neural network) were trained to temporally locate each sample based solely and exclusively on the number of cycles determined in the rRT-PCR of each individual. Overall, this study suggests that there is valuable residual information in the rRT-PCR positive samples that can be used to identify patterns in the development of the SARS-CoV-2 pandemic. The successful application of supervised classification algorithms to detect these patterns demonstrates the potential of machine learning techniques to aid in understanding the spread of the virus and its variants.

Normative values for handgrip strength in Colombian children and adolescents from 6 to 17 years of age: estimation using quantile regression.

OBJECTIVE: The objective of this study is twofold: i) to estimate the normative values for handgrip strength and relative handgrip strength, specific to sex and age, for Colombian children and adolescents from 6 to 17 years of age using quantile regression models and ii) to compare the normative values for handgrip strength and relative handgrip strength in Colombian children and adolescents with those in children and adolescents in different countries. METHOD: This was a cross-sectional analysis of a sample of 2647 youngsters. Handgrip strength was evaluated with a TKK 5101 digital dynamometer (Takei Scientific Instruments Co., Ltd., Tokyo, Japan). The relative handgrip strength was estimated according to weight in kilograms. The normative values were estimated to handgrip strength and relative handgrip strength through quantile regression models for the percentiles P5, P10, P25, P50, P75, P90, and P95 developed independently for each sex. All analyses were adjusted for the expansion factor. RESULTS: The values for handgrip strength were considerably higher in males than in females in all age ranges. Additionally, as age increased for both sexes, the values for handgrip strength increased. The percentiles by sex and age for relative handgrip strength show for males a proportional increase according to age; for females, this did not occur. CONCLUSIONS: When making comparisons with international studies, variability is observed in the methodologies used to evaluate handgrip strength and estimation methods, which could influence the discrepancies between the different reports.

[Anthropometric and body composition characteristics associated with handgrip strength in children and adolescents. A scoping review]. / Características antropométricas y de composición corporal asociadas a la fuerza prensil manual en niños y adolescentes. Una Revisión Sistemática Exploratoria.

Handgrip strength is a robust indicator of the biological health of children and adolescents. Objecti ves: to identify the anthropometric characteristics and body composition related to handgrip stren gth, and to describe the main characteristics of the protocols used for its evaluation. METHODOLOGY: A scoping review was developed; the search was carried out in 1.) Medline; 2.) Web of Science; 3.) Science Direct; 4.) Scielo; and 5.) EBSCO's Sportdiscus. Original investigations were included if they have handgrip strength data, anthropometric characteristics, and body composition. RESULTS: 59 reports published between 2005 and 2020 were selected. Among them, nutritional classification was the most studied characteristic (n = 25; 42.3%), followed by body mass index (n = 23; 38.9%). In 47.5% (28 reports), the number of tests performed on each individual to estimate the handgrip strength value was not clear. The dynamometer brand Takei Scientific Instrument Co. Ltd. was the most used, with 49.2 %. The most widely used indicator was absolute handgrip (86.4%, 51 reports). CONCLUSIONS: There is a wide variety of protocols used for handgrip strength assessment with va riations in body position, arm and hand selection, number of repetitions, and intervals between measurements. A proportional pattern of values was found between absolute handgrip strength and body mass index, Σ skinfolds, however, when adjusted by mass (relative handgrip strength), the relationship is inverse.

Prediction Model for Physical Activity Level in Primary School Students.

The aim of this study was to provide an explanatory prediction model for physical activity level in children, involving a number of influencing variables. In total, 1971 people participated in the study: 657 primary school students and their respective fathers and mothers from 15 schools of Galicia (Spain). The International Questionnaire on Physical Education, Health and Lifestyle was administered. The findings revealed that school year, sex, physical perceived competence and sport practice with friends had a statistically significant relationship on physical activity index. By contrast, the association between the weekly participation of fathers or mothers in sports in the practice of children could not be confirmed. Sport practice with friends was the main predicting variable for physical activity level. Physical perceived competence showed great relevance as well. This knowledge could be of interest to help increase adherence to practice and preventing withdrawal, helping students to stay active and acquire healthy habits for the future.

Impact of New Systemic Therapies in Overall Survival in Non-Metastatic Castration Resistant Prostate Cancer: Systematic Review and Meta-Analysis.

There was a high medical need for patients with non-metastatic castration-resistant prostate cancer (nmCRPC) when several next-generation anti-androgens (apalutamide, enzalutamide, and darolutamide) demonstrated clinically relevant delays in metastasis onset. However, to date, few publications have assessed the pooled effect of these treatments on overall survival (OS). We performed a systematic review and meta-analysis of all randomized, placebo-controlled studies investigating a systemic treatment in nmCRPC. Publications were identified by searching several databases on April 7, 2021. The primary objective of this analysis was to determine the OS benefit. Secondary outcomes included the relative risk (RR) of adverse events (AEs) and grade 3-4 AEs. A sensitivity analysis with simulated data was also conducted to examine the influence of the study designs on the results. Three randomized controlled studies (SPARTAN, PROSPER, ARAMIS) met our inclusion criteria. Pooled meta-analyses showed a significant benefit in OS with the active agents versus placebo (hazard ratio [HR] 0.74, 95% confidence interval [CI] 0.65-0.83), as well as increased risk of any grade (RR 1.09, 95% CI 1.01-1.17) and grade 3-4 AEs (RR 1.50, 95% CI 1.23-1.83). The sensitivity analysis with SPARTAN-like simulated populations demonstrated that when using ARAMIS statistical design, OS would be statistically significant in 98.1% of the cases, at a shorter follow-up and with lower number of events. First-line treatment of nmCRPC patients with anti-androgens increased OS with an acceptable safety profile. In light of the different study designs and follow-up, results should be interpreted separately.

[Prevalence of vitamin D deficiency and insufficiency and associated factors in Colombian women in 2015]. / Prevalencia de la deficiencia e insuficiencia de vitamina D y factores asociados en mujeres colombianas en el 2015.

Introduction: Introduction: vitamin D is a fundamental biomolecule for multiple biological processes in women of childbearing age; it is also one of the most important biomarkers in reproduction. Objective: to determine the prevalence of vitamin D deficiency and insufficiency and associated factors in Colombian women between 18 and 49 years of age. Methodology: an analytical cross-sectional study; it is a secondary analysis of the Encuesta de Situación Nutricional de Colombia, of 2015. A total of 7181 women between 18 and 49 years old, of childbearing age, who were not pregnant were evaluated. Vitamin D levels were estimated through chemiluminescence immunoassay. Sociodemographic, anthropometric and frequency-of-food-consumption characteristics were evaluated. A general description of the prevalence of vitamin D insufficiency and deficiency was made for each of the variables of interest through absolute and percentage frequencies. To estimate the association between the different characteristics of interest and vitamin D insufficiency and deficiency, multivariate binomial and multinomial logistic regression models were used. Results: the prevalence of vitamin D deficiency was 23.8 % and that of insufficiency was 46.8 %; for insufficiency and deficiency the result was 70.6 %. Quartile IV of wealth (OR: 3.21; 95% CI: 2.16-4.77); abdominal obesity (OR: 1.43; IC 95 %: 1.15-1.78), and the Bogotá region (OR: 3.98; 95 % CI: 2.48-6.38) showed an association with vitamin D insufficiency and deficiency. Conclusion: a high prevalence of vitamin D insufficiency and deficiency was identified. Therefore, comprehensive interventions involving nutritional and educational components are recommended.

Introducción: Introducción: la vitamina D es una biomolécula fundamental para múltiples procesos biológicos de la mujer en edad fértil; es también uno de los biomarcadores más importantes para la reproducción. Objetivo: determinar la prevalencia de la deficiencia e insuficiencia de vitamina D y los factores asociados en mujeres colombianas de 18 a 49 años de edad. Metodología: estudio transversal-analítico; se trata de un análisis secundario de la Encuesta de Situación Nutricional de Colombia, del año 2015. Se evaluaron 7181 mujeres de entre 18 y 49 años, en edad fértil, que no estuvieran en embarazo. La vitamina D se estimó a través de quimiolumiscencia por inmunoensayo. Se evaluaron características sociodemográficas, antropométricas y de frecuencia de consumo de alimentos. Se realizó la descripción de la prevalencia de la insuficiencia y deficiencia de vitamina D general y por cada una de las variables de interés a través de frecuencias absolutas y porcentuales. Para estimar la asociación entre las diferentes características de interés y la insuficiencia y la deficiencia de vitamina D se utilizaron modelos de regresión logística multinomial y binomial multivariados. Resultados: la prevalencia de la deficiencia de vitamina D fue del 23,8 % y la insuficiencia del 46,8 %; entre insuficiencia y deficiencia, el resultado fue del 70,6 %; el cuartil IV de riqueza (OR: 3,21; IC 95 %: 2,16-4,77), la obesidad abdominal (OR: 1,43; IC 95 %: 1,15-1,78), y la región de Bogotá (OR: 3,98; IC 95 %: 2,48-6,38) mostraron asociación con la insuficiencia y la deficiencia de vitamina D. Conclusión: se identificó una alta prevalencia de insuficiencia y de deficiencia de vitamina D, por lo que se recomiendan intervenciones integrales en las que estén involucrados los componentes nutricional y educativo.

Influence of the Perception of Barriers in Practice of PA in Adolescents: Explanatory Model.

BACKGROUND: Sedentarism is an important risk factor for non-communicable diseases. To avoid it, it is necessary to establish the barriers which influence a low level of practice of Physical Activity. METHODS: This study, conducted with 833 students, aims to describe a model to explain the barriers determining the level of practice of Physical Activity in adolescents according to age, school year, BMI and gender. The inclusion of the analyzed barriers followed the tetra-factorial model: Body image/physical and social anxiety; Tiredness/laziness; Responsibilities/lack of time and Environment/facilities. RESULTS: The barriers to Physical Activity in adolescents are fatigue and sloth, and temporary obligations. The barrier that least influences the practice of Physical Activity is the environment and body image. It is determined that the subjects with the lowest Physical Activity index were those with a high fatigue and laziness score and higher age. The level of physical activity of this population is medium (95% CI, 2.8274-2.9418). CONCLUSIONS: It is necessary to overcome tiredness or apathy towards the practice of Physical Activity, especially in those under 16 years of age.

Deficiencia de ferritina en gestantes colombianas y factores sociodemográficos asociados / Ferritin deficiency in colombian pregnant women and associated sociodemographic factors / Deficiencia de ferritina en gestantes colombianas y factores sociodemográficos asociados

Objetivo: la ferritina es importante en el almacenamiento de hierro intracelular, en una forma soluble no tóxica. Sus niveles en la gestación se la relacionan con la salud de la madre y con su descendencia. El objetivo es escribir los niveles séricos de ferritina y prevalencia de déficit de ferritina, así como los factores sociodemográficos asociados en gestantes de Colombia. Metodología: estudio transversal; análisis secundario de la Encuesta de Situación Nutricional de Colombia, 2015. Se evaluaron en 1.234 embarazadas con edades entre 12 y 48 años: sus características sociodemográficas y antropométricas, la distribución de los niveles séricos y la prevalencia de déficit de ferritina. Para estimar la asociación entre las diferentes variables sociodemográficas y los niveles séricos, o la prevalencia de déficit de ferritina, se utilizaron modelos de regresión multivariables. Resultados: la prevalencia de deficiencia de ferritina fue de 44.5 % (IC 95 % 40.1 % a 49.0 %), los niveles séricos de ferritina oscilaron entre 4 µg/L y 295,7 µg/L, con un promedio de 29.3 µg/L (IC 95 % 26,5 µg/L-32.2 µg/L). Las gestantes del segundo (OR (OR 2.19 IC 95 % 1.50 a 3.19) y tercer trimestre (OR 3.84 IC 95 % 2.68 a 5.50), aquellas que residen en la región Atlántica (OR 2.18 IC 95 % 1.25 a 3.82) y en la región Orinoquia (OR 2.41 IC 95 %1.19 a 4.88), mostraron asociación con el déficit de ferritina. Conclusión: se halló alta prevalencia en el déficit de ferritina en gestantes colombianas.

Introduction: Ferritin is important in the storage of intracellular iron, in a non-toxic soluble form. Its levels during pregnancy are related to the health of the mother and her offspring. Objective: To describe the serum ferritin levels and the prevalence of ferritin deficiency, and the associated sociodemographic factors in pregnant women in Colombia. Methodology: Cross-sectional study; secondary analysis of the Nutritional Situation Survey of Colombia, 2015. The following were evaluated in 1,234 pregnant women aged between 12 and 48 years: their sociodemographic and anthropometric characteristics, the distribution of serum levels, and the prevalence of ferritin deficiency. To estimate the association between the different sociodemographic variables and serum levels, or the prevalence of ferritin deficiency, multivariate regression models were used. Results: The prevalence of ferritin deficiency was 44.5% (95% CI 40.1% to 49.0%), serum ferritin levels ranged from 4 µg/L to 295.7 µg/L, with a average of 29.3 µg/L (95% CI 26.5 µg/L - 32.2 µg/L). Pregnant women in the second (OR (OR 2.19 95% CI 1.50 to 3.19) and third trimester (OR 3.84 95% CI 2.68 to 5.50), those residing in the Atlantic region ( OR 2.18 95% CI 1.25 to 3.82) and in the Orinoquia region (OR 2.41 95% CI 1.19 to 4.88), showed an association with ferritin deficiency. Conclusion: A high prevalence of ferritin deficiency was found in Colombian pregnant women.

Síndrome de caídas y factores asociados en personas mayores indígenas de nariño, colombia

Objetivo: Determinar los factores asociados al síndrome de caída en un grupo de personas mayores indígenas. Material y Método: Estudio descriptivo transversal, realizado con 518 indígenas mayores de 60 años, que estimó la prevalencia del síndrome de caída durante el año 2019. Los instrumentos utilizados fueron entrevista demográfica y antecedentes médicos, Evaluación Mini Nutricional (MNA por su sigla en inglés) para evaluar estado nutricional, Mini Examen del Estado Mental (MMSE por su sigla en inglés) y The Rowland Universal Dementia Assessment Scale (RUDAS) para determinar nivel cognitivo; la sintomatología depresiva se evaluó con la Escala de Depresión Geriátrica de Yesavage; el nivel funcional se valoró con la escala de Actividades Instrumentales de la Vida Diaria IADL. Se utilizaron modelos de regresión logística multivariable para examinar la asociación entre las variables sociodemográficas y la presencia de morbilidades. Se construyeron perfiles de riesgo entre individuos para estimar la probabilidad de caer a través del análisis de clases latentes. Resultados: 35,9% de los participantes presentó al menos una caída. Hombres (OR 0,55 IC del 95%: 0,38-0,80), personas con hipertensión arterial (OR 3,4 IC del 95%: 1,4-8,2), enfermedad coronaria (OR 2,5 IC del 95%: 1,3 -5,0), artritis o artrosis (OR 1,5 IC del 95%: 1,0-2,0), personas con quejas de memoria (OR 1,6 95% CI 1,1-2,5) y dependencia funcional (OR 1,6 95% CI 1,1-2,2), mostraron una asociación con este síndrome. El perfil de riesgo mostró que los sujetos con mayor número de comorbilidades tenían mayor probabilidad de caídas (0,163). Conclusiones: La prevalencia del síndrome de caídas es similar a la reportada en estudios previos. Comorbilidades propias de la vejez mostraron relación con un mayor riesgo de caídas. Se observa una relación directamente proporcional entre la cantidad de comorbilidades y mayor riesgo de caídas.

Objective: To determine the factors associated with the fall syndrome in a group of indigenous older adults. Materials and Methods: Cross-sectional descriptive study carried out with 518 indigenous people over 60 years of age that estimated the prevalence of the fall syndrome during the year 2019. Research instruments included demographic interview and medical history, Mini Nutritional Assessment (MNA) to assess nutritional status, Mini-Mental State Examination (MMSE) and RUDAS to determine cognitive performance; depressive symptomatology was assessed with the Geriatric Depression Scale by Yesavage; functional level was assessed using Instrumental Activities of Daily Living scale (IADL). Multivariate logistic regression models were used to examine the association between sociodemographic variables and the presence of morbidities. Between-individual risk profiles were set up to estimate the probability of falling, using latent class analysis. Results: 35.9% of participants had at least suffered one fall. Men (OR 0.55 95% CI 0.38-0.80), people with high blood pressure (OR 3.4 95% CI 1.4-8.2), coronary heart disease (OR 2.5 95% CI 1.3 -5.0), arthritis or osteoarthritis (OR 1.5 95% CI 1.0-2.0), people with memory complaints (OR 1.6 95% CI 1.1-2.5) and functional dependency (OR 1.5 95% CI 1.0-2.2), showed an association with this syndrome. The risk profile showed that subjects with a greater number of comorbidities were more likely to suffer a fall (0.163). Conclusions: The prevalence of the falls syndrome is similar to that reported in previous studies. Comorbidities associated with old age showed a relationship with a higher risk of falls. A directly proportional relationship was observed between the number of comorbidities and the increased risk of falls.

Objetivo: Determinar os fatores associados à síndrome de queda em um grupo de idosos indígenas. Material e Métodos: Estudo descritivo transversal, realizado com 518 indígenas com mais de 60 anos de idade, que estimou a prevalência da síndrome de quedas durante o ano de 2019. Os instrumentos utilizados incluíram entrevista demográfica e histórico médico, Mini Avaliação Nutricional (MNA sigla em inglês) para avaliar o estado nutricional, Mini Exame do Estado Mental (MMSE sigla em inglês) e RUDAS para determinar o nível cognitivo; a sintomatologia depressiva foi avaliada com a escala de Depressão Geriátrica de Yesavage; o nível funcional foi avaliado com a escala Atividades Instrumentais de Vida Diária (AIVD). Modelos de regressão logística multivariada foram usados para examinar a associação entre variáveis sociodemográficas e a presença de morbidades. Perfis de risco entre indivíduos foram construídos para estimar a probabilidade de queda, por meio de análise de classe latente. Resultados: 35,9% dos participantes sofreram pelo menos uma queda. Homens (OR 0,55 IC 95% 0,38-0,80), pessoas com hipertensão arterial (OR 3,4 IC 95% 1,4-8,2), doença coronariana (OR 2,5 IC 95% 1,3-5,0), artrite ou osteoartrite (OR 1,5 IC 95% 1,0-2,0), pessoas com queixas de memória (OR 1,6 IC 95% 1,1-2,5) e dependência funcional (OR 1,5 IC 95% 1,0-2,2) apresentaram associação com essa síndrome. O perfil de risco mostrou que indivíduos com um número maior de comorbidades tinham maior probabilidade de cair (0,163). Conclusões: A prevalência da síndrome de quedas é semelhante à descrita em estudos anteriores. As comorbidades características da idade avançada mostraram uma relação com o aumento do risco de quedas. Observa-se uma relação diretamente proporcional entre o número de comorbidades e o aumento do risco de quedas.

Prevalence of the Consumption of Tranquilizers without a Medical Prescription and Associated Factors in School-Based Adolescents in Colombia / Prevalencia del consumo de tranquilizantes sin prescripción médica y factores asociados en adolescentes escolarizados de Colombia / Prevalência do uso de tranquilizantes sem prescrição médica e fatores associados em adolescentes em idade escolar na Colômbia

Introduction: Non-prescription tranquilizers are a specific group of benzodiazepines, used as drugs that act on the central nervous system and have an extensive effect in patients with anxiety disorders and problems in sleep stages. Objective: To determine the prevalence of the year and month of consumption of tranquilizers without a medical prescription and the associated factors, in adolescents in school in Colombia. Methods: It is a cross-sec-tional study with an analytical scope. The universe of the study consisted of 3,243,377 students, from grades 7 to 11 (aged between 12 and 18 years), the valid surveys were 80,018. The adolescent who declared having used tranquilizers during the last 30 days and the last 12 months was considered a consumer. All variables were self-re-ported by adolescents. Results: The prevalence of tranquilizer use without medical prescription was 1.02% and 1.97% (month and year, respectively). Adolescents who presented disciplinary problems are the most predisposed to use during the last month with an OR 2.79 (95% CI: 2.20­3.53) and last year an OR of 2.77 (95 % CI: 2.34­3.27). Conclusions: There is a higher prevalence of the consumption of tranquilizers without medical prescription in women between 14 and 17 years of age, from mixed schools and it is associated with academic and disciplinary performance problems, in the last year. In addition, as age increases, the consumption of substances without a medical prescription increases

Introducción: Los tranquilizantes sin prescripción médica son un grupo específico de benzodiacepinas, usados como medicamentos que actúan sobre el sistema nervioso central y cuentan con un extenso efecto en pacientes con trastornos de ansiedad y problemas en las etapas del sueño. Objetivo: Determinar la prevalencia de año y mes de consumo de tranquilizantes sin prescripción médica y los factores asociados en adolescentes escolarizados de Colombia. Métodos: Estudio transversal con alcance analítico. El universo del estudio estuvo constituido por 3 243 377 estudiantes de los gados 7.º a 11.º (con edades entre 12 y 18 años). Las encuestas válidas fueron 80 018. Se consideró consumidor al adolescente que declaró haber consumido tranquilizantes durante los últimos 30 días y los últimos 12 meses. Todas las variables fueron autorreportadas por los adolescentes. Resultados: La prevalencia de consumo de tranquilizantes sin prescripción médica fue del 1,02 % y del 1,97 % (mes y año, respectivamente). Los adolescentes que presentaron problemas disciplinarios son los más predispuestos al consumo durante el último mes con un OR de 2,79 (IC95 %: 2,20-3,53) y último año un OR de 2,77 (IC95 %: 2,34-3,27). Conclusiones: Existe mayor prevalencia de consumo de tranquilizantes sin prescripción médica en mujeres entre los 14 y los 17 años, de colegios mixtos, y se encuentra asociada con problemas de rendimiento académico y disciplinarios, en el último año. Además, a medida que aumenta la edad, se incrementa el consumo de sustancias sin prescripción médica

Introdução: Os tranquilizantes isentos de prescrição são um grupo específico de benzodiazepínicos, usados como medicamentos que atuam no sistema nervoso central e têm um efeito extenso em pa-cientes com transtornos de ansiedade e problemas no estágio do sono. Objetivo: Determinar a prevalência anual e mensal do uso de tranquilizantes sem prescrição médica e os fatores associados em adolescentes em idade escolar na Colômbia. Métodos: Estudo transversal com escopo analítico. O universo do estudo consistiu em 3243377 alunos da 7ª à 11ª série (com idades entre 12 e 18 anos). Foram realizadas 80018 pesquisas válidas. Um adolescente foi considerado usuário, o qual relatou ter usado tranquilizantes nos últimos 30 dias e nos últimos 12 meses. Todas as variáveis foram autorrelatadas pelos adolescentes. Resultados: A prevalência do uso de tranquilizantes sem prescrição médica foi de 1,02% e 1,97% (mês e ano, respectivamente). Os adolescentes com problemas disciplinares apresentaram maior pro-babilidade de uso no último mês, com um OR de 2,79 (IC95%: 2,20-3,53) e no último ano, com um OR de 2,77 (IC95%: 2,34-3,27). Conclusões: Há uma maior prevalência de uso de tranquilizantes sem prescrição médica em mulheres de 14 a 17 anos, de escolas mistas, e isso está associado a problemas de desempenho acadêmico e disciplinar no último ano. Além disso, com o aumento da idade, aumenta o uso de substâncias sem prescrição médica.

Validez de constructo y la confiabilidad del cuestionario MOS de apoyo social en estudiantes universitarios

El apoyo social ha sido definido como "un intercambio de recursos entre al menos dos personas, percibidas por el proveedor o el receptor con el objetivo de mejorar el bienestar del receptor". Metodología: Estudio descriptivo transversal, con una muestra de 542 individuos universitarios, mayores de 18 años, seleccionados a conveniencia. Se evaluaron características sociodemográficas, y se aplicó el cuestionario Medical Outcomes Study-Social Support Survey. Para evaluar la estructura jerárquica se utilizó la técnica "análisis factorial exploratorio por medio del método de componentes principales", con rotación varimax, según el grado de correlación existente entre ellos. Por intermedio de la prueba de esfericidad de Bartlett se determinó el determinante de la matriz de correlaciones y la prueba de Kaiser-Meyer-Olkin (válido con valores por encima de 0.5). Para estimar "confiabilidad" se usó el coeficiente omega, posterior a la consolidación de los factores. Resultados: Se obtuvo información de 510 individuos, de los cuales 263 fueron mujeres (51,6 %); la edad promedio fue 24,8, con una desviación estándar de 2,6. Se estimaron 3 factores para el análisis factorial exploratorio que explicaban el 63.559 % de la varianza. Las cargas factoriales de los ítems que componen el instrumento oscilaron entre 0,442 a 0,784. La consistencia interna por factor presentó puntajes de coeficiente, omega que fluctuaban entre 0,850 y 0,940 y un omega general de 0,920. Conclusión: La validez de constructo y la confiabilidad del cuestionario en estudiantes universitarios muestran valores aceptables; no obstante, esos resultados deben ser usados con cautela, pues es necesario desarrollar otros estudios que corroboren los resultados de nuestro estudio.

Social support is defined as "an exchange of resources between at least two people, from the provider's or the recipient's perspective aiming to improve the recipient's well-being condition». Methodology: It is a descriptive cross-sectional study which included 542 university students over 18 years of age, sampled at convenience; sociodemographic characteristics were evaluated, and we applied the Medical Outcomes Study-Social Support Survey questionnaire. To evaluate the hierarchical structure, the technique "exploratory factor analysis by means of the principal components method" was used, whit varimax rotation, according to the degree of correlation between them. The correlation matrix's determinant and the Kaiser-Meyer-Olkin test (valid with values above 0.5) were established through Bartlett's sphericity test. To estimate reliability, Omega coefficient was used after factors' consolidation. Results: Information was obtained from 510 individuals, of which 263 were female (51.6 %); the average age was 24.8 with a standard deviation of S.D 2.6. Three factors were estimated for the exploratory factor analysis, explaining 63.559 % of the variance. The internal consistency by factor presented omega coefficient values ranged from 0.850 to 0.940 and an overall general omega of 0.920. Conclusion: Construct validity and reliability of the questionnaire in university students show acceptable values; However, these results should be used with caution, as further analyses should be developed corroborate our study's results.

Normative values for handgrip strength in Colombian children and adolescents from 6 to 17 years of age: estimation using quantile regression

Abstract Objective: The objective of this study is twofold: i) to estimate the normative values for handgrip strength and relative handgrip strength, specific to sex and age, for Colombian children and adolescents from 6 to 17 years of age using quantile regression models and ii) to compare the normative values for handgrip strength and relative handgrip strength in Colombian children and adolescents with those in children and adolescents in different countries. Method: This was a cross-sectional analysis of a sample of 2647 youngsters. Handgrip strength was evaluated with a TKK 5101 digital dynamometer (Takei Scientific Instruments Co., Ltd., Tokyo, Japan). The relative handgrip strength was estimated according to weight in kilograms. The normative values were estimated to handgrip strength and relative handgrip strength through quantile regression models for the percentiles P5, P10, P25, P50, P75, P90, and P95 developed independently for each sex. All analyses were adjusted for the expansion factor. Results: The values for handgrip strength were considerably higher in males than in females in all age ranges. Additionally, as age increased for both sexes, the values for handgrip strength increased. The percentiles by sex and age for relative handgrip strength show for males a proportional increase according to age; for females, this did not occur. Conclusions: When making comparisons with international studies, variability is observed in the methodologies used to evaluate handgrip strength and estimation methods, which could influence the discrepancies between the different reports.