Detalhe da pesquisa
1.
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J Med Chem
; 65(8): 6001-6016, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239336
2.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475697
3.
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors.
ACS Med Chem Lett
; 12(9): 1435-1440, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531952
4.
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
ACS Med Chem Lett
; 12(11): 1678-1688, 2021 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34795856
5.
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
ACS Med Chem Lett
; 12(3): 389-396, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738066
6.
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
ACS Med Chem Lett
; 11(4): 582-588, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292567
7.
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.
ACS Med Chem Lett
; 10(11): 1530-1536, 2019 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749906
8.
Synthesis of the bis-tetrahydropyran core of amphidinol 3.
Org Lett
; 12(17): 3890-3, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20795745
9.
Artificial genetic systems: exploiting the "aromaticity" formalism to improve the tautomeric ratio for isoguanosine derivatives.
J Org Chem
; 69(11): 3972-5, 2004 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15153036
10.
Synthesis, structure, and biological evaluation of novel N- and O-linked diinositols.
J Am Chem Soc
; 124(35): 10416-26, 2002 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12197743
11.
Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives.
J Org Chem
; 67(25): 8726-43, 2002 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12467383