Detalhe da pesquisa
1.
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.
Blood
; 141(26): 3166-3183, 2023 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37084385
2.
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
J Biol Chem
; 295(33): 11656-11668, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32571877
3.
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.
Mol Oncol
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38533616
4.
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
iScience
; 27(2): 108907, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38318365
5.
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Nat Metab
; 5(4): 642-659, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37012496
6.
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.
Cell Death Differ
; 29(1): 246-261, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34453118
7.
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science
; 376(6600): 1471-1476, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35737787
8.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
9.
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Nat Commun
; 9(1): 3872, 2018 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30250201
10.
Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster.
Basic Clin Pharmacol Toxicol
; 119(3): 309-16, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27009472