1.
Eur J Haematol
; 95(4): 257-69, 2015 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25881749
RESUMO
Genomic studies have led to a significant impact both on the pace and the nature of understanding the molecular and biological bases of a variety of lymphoid tumors. An increasingly emerging aspect from genomic studies is that malignant lymphoid cells manipulate signaling pathways that are central to the homeostasis of their normal counterpart, including B- and T-cell receptor signaling, NF-κB signaling, Toll-like receptor signaling, cytokine signaling, MAP kinase signaling, and NOTCH signaling. This review aims at covering the signaling pathways that are affected by mutations in lymphoid tumors, and how genetic alteration of these pathways may contribute to disease pathogenesis and management.
Assuntos
Leucemia Linfoide/metabolismo , Linfoma/metabolismo , Transdução de Sinais , Animais , Citocinas/metabolismo , Regulação Neoplásica da Expressão Gênica , Humanos , Leucemia Linfoide/genética , Leucemia Linfoide/terapia , Linfoma/genética , Linfoma/terapia , Sistema de Sinalização das MAP Quinases , NF-kappa B/metabolismo , Receptores de Antígenos de Linfócitos B/metabolismo , Receptores de Antígenos de Linfócitos T/metabolismo , Receptores Notch/metabolismo , Receptores Toll-Like/metabolismo
2.
Haematologica
; 101(4): e135-8, 2016 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26819056