Detalhe da pesquisa
1.
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22.
PLoS Pathog
; 18(1): e1010200, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35025968
2.
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
Nature
; 489(7414): 155-9, 2012 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22820254
3.
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.
Blood
; 126(22): 2479-83, 2015 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26443624
4.
Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.
Blood
; 124(14): 2280-4, 2014 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25115888
5.
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.
Blood
; 123(13): 2075-83, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24470592
6.
Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis.
Blood
; 115(14): 2919-27, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20154217
7.
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
J Immunother Cancer
; 8(2)2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33243932
8.
JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response.
Cancer Discov
; 5(3): 316-31, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25572172
9.
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.
J Exp Med
; 209(2): 259-73, 2012 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22271575
10.
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
J Clin Invest
; 120(10): 3578-93, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20852385
11.
A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.
Nat Genet
; 41(4): 455-9, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19287384