Detalhe da pesquisa
1.
Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(12): 3715-20, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21571529
2.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2195-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207136
3.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
Bioorg Med Chem Lett
; 20(12): 3502-6, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529683
4.
Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.
J Med Chem
; 50(21): 5161-7, 2007 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880055
5.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713656
6.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190552
7.
Identification of gamma-secretase inhibitor potency determinants on presenilin.
J Biol Chem
; 283(5): 2927-38, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032377