Detalhe da pesquisa
1.
Utilization of Cyclic Amides as Masked Aldehyde Equivalents in Reductive Amination Reactions.
J Org Chem
; 84(12): 7936-7949, 2019 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31117567
2.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712838
3.
Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(1): 31-5, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19062274
4.
Correction to "Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement".
ACS Med Chem Lett
; 8(3): 378, 2017 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337335
5.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
J Med Chem
; 60(14): 5990-6017, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28324649
6.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
J Med Chem
; 60(14): 5969-5989, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28287723
7.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.
ACS Med Chem Lett
; 7(12): 1062-1067, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994738
8.
Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene ß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem
; 57(23): 9796-810, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25389560
9.
Inhibitors of ß-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).
J Med Chem
; 57(23): 9811-31, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25363711