Detalhe da pesquisa
1.
Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and pharmacodynamics studies of KDM1A inhibitors.
J Biol Chem
; 294(20): 8311-8322, 2019 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30804215
2.
Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis.
Pharmaceutics
; 14(7)2022 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35890315
3.
Comprehensive in Vitro Characterization of the LSD1 Small Molecule Inhibitor Class in Oncology.
ACS Pharmacol Transl Sci
; 4(6): 1818-1834, 2021 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34927013
4.
First-in-Human Randomized Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the KDM1A Inhibitor Vafidemstat.
CNS Drugs
; 35(3): 331-344, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33755924
5.
First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia.
J Clin Oncol
; 38(36): 4260-4273, 2020 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33052756
6.
Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.
PLoS One
; 15(5): e0233468, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32469975
7.
Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays.
J Vis Exp
; (148)2019 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31259886
8.
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Cancer Cell
; 33(3): 495-511.e12, 2018 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29502954
9.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
Mol Cancer Res
; 4(9): 645-53, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16940161
10.
KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.
Epigenomics
; 7(4): 609-26, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26111032
11.
A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.
mBio
; 4(1): e00558-12, 2013 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23386436
12.
Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo.
Mol Ther Nucleic Acids
; 1: e42, 2012 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23344234
13.
Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration.
Mol Cell Neurosci
; 28(4): 599-612, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15797708