Detalhe da pesquisa
1.
Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.
Bioorg Med Chem Lett
; 26(15): 3414-20, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27394665
2.
Reversible cysteine protease inhibitors show promise for a Chagas disease cure.
Antimicrob Agents Chemother
; 58(2): 1167-78, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24323474
3.
Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
Bioorg Med Chem Lett
; 21(5): 1488-92, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295979
4.
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 21(3): 920-3, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21232956
5.
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease.
Bioorg Med Chem Lett
; 20(24): 7444-9, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21041084
6.
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).
Bioorg Med Chem Lett
; 20(2): 499-502, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004097
7.
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
Bioorg Med Chem Lett
; 20(3): 887-92, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061146
8.
Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools.
Biol Chem
; 390(9): 941-8, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19453281
9.
Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors.
Bioorg Med Chem Lett
; 19(3): 675-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19117756
10.
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Bioorg Med Chem Lett
; 19(20): 5837-41, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19748780
11.
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Bioorg Med Chem Lett
; 18(3): 923-8, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226527
12.
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Bioorg Med Chem Lett
; 17(24): 6816-20, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18029174
13.
Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.
J Med Chem
; 49(3): 1066-79, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451072
14.
Application of the Protein Maker as a platform purification system for therapeutic antibody research and development.
Comput Struct Biotechnol J
; 14: 238-44, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27418955
15.
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Diabetes
; 53(4): 1007-19, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15047616
16.
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
J Med Chem
; 48(24): 7535-43, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302795
17.
An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1.
J Biomol Screen
; 10(6): 599-605, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103419
18.
The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.
ACS Med Chem Lett
; 1(4): 170-4, 2010 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900191
19.
Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.
J Med Chem
; 51(20): 6410-20, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18811135
20.
Primary amides as selective inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 17(15): 4328-32, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17544269