Detalhe da pesquisa
1.
Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
Antimicrob Agents Chemother
; 67(9): e0028423, 2023 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37565762
2.
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
Antimicrob Agents Chemother
; 67(11): e0059723, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791784
3.
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Antimicrob Agents Chemother
; 66(4): e0219221, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266826
4.
Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832.
Antimicrob Agents Chemother
; 65(11): e0058321, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34370580
5.
Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
bioRxiv
; 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798577
6.
Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice.
bioRxiv
; 2023 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36945388
7.
Transcriptional adaptation of Mycobacterium tuberculosis that survives prolonged multi-drug treatment in mice.
mBio
; : e0236323, 2023 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37905920
8.
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J Med Chem
; 65(1): 409-423, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910486
9.
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
J Med Chem
; 64(17): 12790-12807, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34414766