Detalhe da pesquisa
1.
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
J Biol Chem
; 297(5): 101333, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34688659
2.
Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
Am J Hum Genet
; 104(2): 287-298, 2019 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30661771
3.
Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development.
FASEB J
; 35(5): e21473, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811703
4.
The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.
Development
; 143(14): 2616-28, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27287799
5.
Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes.
Diabetes Obes Metab
; 20(8): 1859-1867, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29569324
6.
An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration.
Dev Biol
; 409(2): 354-69, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658317
7.
Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.
PLoS Genet
; 9(2): e1003278, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23408910
8.
Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development.
Dev Dyn
; 243(9): 1116-29, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24979729
9.
A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates ß-Cell Identity and Function.
Diabetes
; 73(3): 461-473, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38055903
10.
Generation of mice encoding a conditional allele of Nkx2.2.
Transgenic Res
; 22(5): 965-72, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23494546
11.
Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
HGG Adv
; 4(3): 100206, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37333770
12.
Deoxyhypusine synthase is required for the translational regulation of pancreatic beta cell maturation.
bioRxiv
; 2023 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37162889
13.
Inhibition of polyamine biosynthesis preserves ß cell function in type 1 diabetes.
Cell Rep Med
; 4(11): 101261, 2023 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37918404
14.
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Diabetes
; 72(4): 433-448, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940317
15.
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.
Dev Biol
; 359(1): 1-11, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21856296
16.
Exocrine-Endocrine Crosstalk: The Influence of Pancreatic Cellular Communications on Organ Growth, Function and Disease.
Front Endocrinol (Lausanne)
; 13: 904004, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35769082
17.
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Pancreas
; 51(9): 1061-1073, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078927
18.
Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas.
BMC Bioinformatics
; 12: 62, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21352540
19.
GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2.
Cereb Cortex
; 20(5): 1234-44, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19767311
20.
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.
Cell Metab
; 33(9): 1883-1893.e7, 2021 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34496231