Detalhe da pesquisa
1.
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Nature
; 538(7626): 477-482, 2016 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27760111
2.
Fragment screening by weak affinity chromatography: comparison with established techniques for screening against HSP90.
Anal Chem
; 85(14): 6756-66, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23806099
3.
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.
Bioorg Med Chem Lett
; 22(2): 901-6, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209458
4.
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg Med Chem
; 20(22): 6770-89, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018093
5.
PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
RSC Med Chem
; 13(11): 1341-1349, 2022 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36426238
6.
Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
Bioorg Med Chem Lett
; 20(2): 586-90, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969456
7.
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.
Commun Chem
; 3(1): 122, 2020 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36703375
8.
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Bioorg Med Chem Lett
; 19(15): 4241-4, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19515560
9.
Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
ACS Omega
; 4(5): 8892-8906, 2019 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31459977
10.
S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
Oncotarget
; 9(28): 20075-20088, 2018 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29732004
11.
Dynamic undocking and the quasi-bound state as tools for drug discovery.
Nat Chem
; 9(3): 201-206, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28221352
12.
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
J Med Chem
; 60(6): 2271-2286, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199108
13.
Towards the discovery of drug-like RNA ligands?
Drug Discov Today
; 11(21-22): 1019-27, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17055412
14.
Structural basis for contrasting activities of ribosome binding thiazole antibiotics.
Chem Biol
; 10(8): 769-78, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12954336
15.
The bacterial ribosome, a promising focus for structure-based drug design.
Curr Opin Pharmacol
; 2(5): 501-6, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12324250
16.
RNA as a drug target.
Prog Med Chem
; 39: 73-119, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12536671
17.
Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products.
J Med Chem
; 57(7): 2845-50, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24520903
18.
VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.
Oncotarget
; 5(24): 12862-76, 2014 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25404640
19.
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
J Med Chem
; 54(12): 4034-41, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21526763
20.
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
Cancer Chemother Pharmacol
; 66(3): 535-45, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20012863