Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Novel Physics-Based Ensemble Modeling Approach That Utilizes 3D Molecular Conformation and Packing to Access Aqueous Thermodynamic Solubility: A Case Study of Orally Available Bromodomain and Extraterminal Domain Inhibitor Lead Optimization Series.
J Chem Inf Model
; 61(3): 1412-1426, 2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33661005
3.
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29084747
4.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678460
5.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268136
6.
Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.
Bioorg Med Chem Lett
; 22(6): 2212-5, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342631
7.
Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML.
In Vivo
; 36(4): 1615-1627, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35738590
8.
Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia.
Mol Cancer Ther
; 20(10): 1809-1819, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34253595
9.
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
J Med Chem
; 63(10): 5585-5623, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324999
10.
Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.
Bioorg Med Chem Lett
; 18(5): 1692-5, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242993
11.
Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.
J Med Chem
; 61(12): 5138-5153, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29852069
12.
HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues.
Mol Cancer Ther
; 16(2): 388-396, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27903752
13.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416490
14.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368119
15.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
16.
Preparation and Diazodecomposition Reaction of an alpha-Diazocarbonyl-Tethered Tricarbonyl(eta(4)-cyclohexadiene)iron Complex.
J Org Chem
; 61(13): 4188-4189, 1996 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667309
17.
Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir.
J Med Chem
; 52(9): 2964-70, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19348416
18.
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.
J Med Chem
; 52(23): 7604-17, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19954246
19.
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.
Bioorg Med Chem Lett
; 17(8): 2289-92, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17300933
20.
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
Bioorg Med Chem Lett
; 16(14): 3833-8, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16650984