Pesquisa | Biblioteca Virtual em Saúde

1.

Structural basis for isoform-specific inhibition of human CTPS1.

Lynch, Eric M; DiMattia, Michael A; Albanese, Steven; van Zundert, Gydo C P; Hansen, Jesse M; Quispe, Joel D; Kennedy, Madison A; Verras, Andreas; Borrelli, Kenneth; Toms, Angela V; Kaila, Neelu; Kreutter, Kevin D; McElwee, Joshua J; Kollman, Justin M.

Proc Natl Acad Sci U S A ; 118(40)2021 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-34583994

2.

Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.

Leit, Silvana; Greenwood, Jeremy R; Mondal, Sayan; Carriero, Samantha; Dahlgren, Markus; Harriman, Geraldine C; Kennedy-Smith, Joshua J; Kapeller, Rosana; Lawson, Jon P; Romero, Donna L; Toms, Angela V; Shelley, Mee; Wester, Ronald T; Westlin, William; McElwee, Joshua J; Miao, Wenyan; Edmondson, Scott D; Masse, Craig E.

Bioorg Med Chem Lett ; 73: 128891, 2022 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-35842205

3.

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis.

Ozen, Ahmet; Comrie, William A; Ardy, Rico C; Domínguez Conde, Cecilia; Dalgic, Buket; Beser, Ömer F; Morawski, Aaron R; Karakoc-Aydiner, Elif; Tutar, Engin; Baris, Safa; Ozcay, Figen; Serwas, Nina K; Zhang, Yu; Matthews, Helen F; Pittaluga, Stefania; Folio, Les R; Unlusoy Aksu, Aysel; McElwee, Joshua J; Krolo, Ana; Kiykim, Ayca; Baris, Zeren; Gulsan, Meltem; Ogulur, Ismail; Snapper, Scott B; Houwen, Roderick H J; Leavis, Helen L; Ertem, Deniz; Kain, Renate; Sari, Sinan; Erkan, Tülay; Su, Helen C; Boztug, Kaan; Lenardo, Michael J.

N Engl J Med ; 377(1): 52-61, 2017 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-28657829

4.

Genetic and Structural Analysis of a SKIV2L Mutation Causing Tricho-hepato-enteric Syndrome.

Vardi, Iddo; Barel, Ortal; Sperber, Michal; Schvimer, Michael; Nunberg, Moran; Field, Michael; Ouahed, Jodie; Marek-Yagel, Dina; Werner, Lael; Haberman, Yael; Lahad, Avishay; Anikster, Yair; Rechavi, Gideon; Barshack, Iris; McElwee, Joshua J; Maranville, Joseph; Somech, Raz; Snapper, Scott B; Weiss, Batia; Shouval, Dror S.

Dig Dis Sci ; 63(5): 1192-1199, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-29484573

5.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Burnett, Camilla; Valentini, Sara; Cabreiro, Filipe; Goss, Martin; Somogyvári, Milán; Piper, Matthew D; Hoddinott, Matthew; Sutphin, George L; Leko, Vid; McElwee, Joshua J; Vazquez-Manrique, Rafael P; Orfila, Anne-Marie; Ackerman, Daniel; Au, Catherine; Vinti, Giovanna; Riesen, Michèle; Howard, Ken; Neri, Christian; Bedalov, Antonio; Kaeberlein, Matt; Soti, Csaba; Partridge, Linda; Gems, David.

Nature ; 477(7365): 482-5, 2011 Sep 21.

Artigo em Inglês | MEDLINE | ID: mdl-21938067

6.

Novel PIK3CD mutations affecting N-terminal residues of p110Î´ cause activated PI3KÎ´ syndrome (APDS) in humans.

Takeda, Andrew J; Zhang, Yu; Dornan, Gillian L; Siempelkamp, Braden D; Jenkins, Meredith L; Matthews, Helen F; McElwee, Joshua J; Bi, Weimin; Seeborg, Filiz O; Su, Helen C; Burke, John E; Lucas, Carrie L.

J Allergy Clin Immunol ; 140(4): 1152-1156.e10, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28414062

7.

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.

Leit, Silvana; Greenwood, Jeremy; Carriero, Samantha; Mondal, Sayan; Abel, Robert; Ashwell, Mark; Blanchette, Heather; Boyles, Nicholas A; Cartwright, Mark; Collis, Alan; Feng, Shulu; Ghanakota, Phani; Harriman, Geraldine C; Hosagrahara, Vinayak; Kaila, Neelu; Kapeller, Rosanna; Rafi, Salma B; Romero, Donna L; Tarantino, Paul M; Timaniya, Jignesh; Toms, Angela V; Wester, Ronald T; Westlin, William; Srivastava, Bhaskar; Miao, Wenyan; Tummino, Peter; McElwee, Joshua J; Edmondson, Scott D; Masse, Craig E.

J Med Chem ; 66(15): 10473-10496, 2023 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-37427891

8.

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO.

Schuster, Eugene; McElwee, Joshua J; Tullet, Jennifer M A; Doonan, Ryan; Matthijssens, Filip; Reece-Hoyes, John S; Hope, Ian A; Vanfleteren, Jacques R; Thornton, Janet M; Gems, David.

Mol Syst Biol ; 6: 399, 2010 Aug 10.

Artigo em Inglês | MEDLINE | ID: mdl-20706209

9.

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.

Patel, Dhaval S; Garza-Garcia, Acely; Nanji, Manoj; McElwee, Joshua J; Ackerman, Daniel; Driscoll, Paul C; Gems, David.

Genetics ; 178(2): 931-46, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18245374

10.

Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase.

Howe, Matthew K; Dowdell, Kennichi; Roy, Amitava; Niemela, Julie E; Wilson, Wyndham; McElwee, Joshua J; Hughes, Jason D; Cohen, Jeffrey I.

Front Immunol ; 10: 2000, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31507602

11.

Human PI3KÎ³ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

Takeda, Andrew J; Maher, Timothy J; Zhang, Yu; Lanahan, Stephen M; Bucklin, Molly L; Compton, Susan R; Tyler, Paul M; Comrie, William A; Matsuda, Makoto; Olivier, Kenneth N; Pittaluga, Stefania; McElwee, Joshua J; Long Priel, Debra A; Kuhns, Douglas B; Williams, Roger L; Mustillo, Peter J; Wymann, Matthias P; Koneti Rao, V; Lucas, Carrie L.

Nat Commun ; 10(1): 4364, 2019 09 25.

Artigo em Inglês | MEDLINE | ID: mdl-31554793

12.

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.

Lamborn, Ian T; Jing, Huie; Zhang, Yu; Drutman, Scott B; Abbott, Jordan K; Munir, Shirin; Bade, Sangeeta; Murdock, Heardley M; Santos, Celia P; Brock, Linda G; Masutani, Evan; Fordjour, Emmanuel Y; McElwee, Joshua J; Hughes, Jason D; Nichols, Dave P; Belkadi, Aziz; Oler, Andrew J; Happel, Corinne S; Matthews, Helen F; Abel, Laurent; Collins, Peter L; Subbarao, Kanta; Gelfand, Erwin W; Ciancanelli, Michael J; Casanova, Jean-Laurent; Su, Helen C.

J Exp Med ; 214(7): 1949-1972, 2017 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-28606988

13.

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

Abolhassani, Hassan; Edwards, Emily S J; Ikinciogullari, Aydan; Jing, Huie; Borte, Stephan; Buggert, Marcus; Du, Likun; Matsuda-Lennikov, Mami; Romano, Rosa; Caridha, Rozina; Bade, Sangeeta; Zhang, Yu; Frederiksen, Juliet; Fang, Mingyan; Bal, Sevgi Kostel; Haskologlu, Sule; Dogu, Figen; Tacyildiz, Nurdan; Matthews, Helen F; McElwee, Joshua J; Gostick, Emma; Price, David A; Palendira, Umaimainthan; Aghamohammadi, Asghar; Boisson, Bertrand; Rezaei, Nima; Karlsson, Annika C; Lenardo, Michael J; Casanova, Jean-Laurent; Hammarström, Lennart; Tangye, Stuart G; Su, Helen C; Pan-Hammarström, Qiang.

J Exp Med ; 214(1): 91-106, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-28011864

14.

Germline hypomorphic CARD11 mutations in severe atopic disease.

Ma, Chi A; Stinson, Jeffrey R; Zhang, Yuan; Abbott, Jordan K; Weinreich, Michael A; Hauk, Pia J; Reynolds, Paul R; Lyons, Jonathan J; Nelson, Celeste G; Ruffo, Elisa; Dorjbal, Batsukh; Glauzy, Salomé; Yamakawa, Natsuko; Arjunaraja, Swadhinya; Voss, Kelsey; Stoddard, Jennifer; Niemela, Julie; Zhang, Yu; Rosenzweig, Sergio D; McElwee, Joshua J; DiMaggio, Thomas; Matthews, Helen F; Jones, Nina; Stone, Kelly D; Palma, Alejandro; Oleastro, Matías; Prieto, Emma; Bernasconi, Andrea R; Dubra, Geronimo; Danielian, Silvia; Zaiat, Jonathan; Marti, Marcelo A; Kim, Brian; Cooper, Megan A; Romberg, Neil; Meffre, Eric; Gelfand, Erwin W; Snow, Andrew L; Milner, Joshua D.

Nat Genet ; 49(8): 1192-1201, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28628108

15.

Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease.

Ma, Chi A; Stinson, Jeffrey R; Zhang, Yuan; Abbott, Jordan K; Weinreich, Michael A; Hauk, Pia J; Reynolds, Paul R; Lyons, Jonathan J; Nelson, Celeste G; Ruffo, Elisa; Dorjbal, Batsukh; Glauzy, Salomé; Yamakawa, Natsuko; Arjunaraja, Swadhinya; Voss, Kelsey; Stoddard, Jennifer; Niemela, Julie; Zhang, Yu; Rosenzweig, Sergio D; McElwee, Joshua J; DiMaggio, Thomas; Matthews, Helen F; Jones, Nina; Stone, Kelly D; Palma, Alejandro; Oleastro, Matías; Prieto, Emma; Bernasconi, Andrea R; Dubra, Geronimo; Danielian, Silvia; Zaiat, Jonathan; Marti, Marcelo A; Kim, Brian; Cooper, Megan A; Romberg, Neil D; Meffre, Eric; Gelfand, Erwin W; Snow, Andrew L; Milner, Joshua D.

Nat Genet ; 49(11): 1661, 2017 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-29074947

16.

Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472].

McElwee, Joshua J; Schuster, Eugene; Blanc, Eric; Thornton, Janet; Gems, David.

Mech Ageing Dev ; 127(12): 922-36, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17216712

17.

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans.

McElwee, Joshua J; Schuster, Eugene; Blanc, Eric; Thornton, Janet; Gems, David.

Mech Ageing Dev ; 127(5): 458-72, 2006 May.

Artigo em Inglês | MEDLINE | ID: mdl-16522328

18.

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

Lyons, Jonathan J; Yu, Xiaomin; Hughes, Jason D; Le, Quang T; Jamil, Ali; Bai, Yun; Ho, Nancy; Zhao, Ming; Liu, Yihui; O'Connell, Michael P; Trivedi, Neil N; Nelson, Celeste; DiMaggio, Thomas; Jones, Nina; Matthews, Helen; Lewis, Katie L; Oler, Andrew J; Carlson, Ryan J; Arkwright, Peter D; Hong, Celine; Agama, Sherene; Wilson, Todd M; Tucker, Sofie; Zhang, Yu; McElwee, Joshua J; Pao, Maryland; Glover, Sarah C; Rothenberg, Marc E; Hohman, Robert J; Stone, Kelly D; Caughey, George H; Heller, Theo; Metcalfe, Dean D; Biesecker, Leslie G; Schwartz, Lawrence B; Milner, Joshua D.

Nat Genet ; 48(12): 1564-1569, 2016 12.

Artigo em Inglês | MEDLINE | ID: mdl-27749843

19.

Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?

Gems, David; McElwee, Joshua J.

Mech Ageing Dev ; 126(3): 381-7, 2005 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-15664624

20.

Ageing: Microarraying mortality.