Detalhe da pesquisa
1.
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications.
Bioorg Med Chem Lett
; 92: 129405, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37414346
2.
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 25(5): 1104-9, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666823
3.
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Bioorg Med Chem Lett
; 24(16): 3782-5, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25042256
4.
Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Bioorg Med Chem Lett
; 23(5): 1238-44, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374866
5.
Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Bioorg Med Chem
; 21(4): 979-92, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23294830
6.
An expeditious synthesis of the MDM2-p53 inhibitor AM-8553.
J Am Chem Soc
; 134(30): 12855-60, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22734631
7.
Imidazo-pyrazine derivatives as potent CXCR3 antagonists.
Bioorg Med Chem Lett
; 19(17): 5200-4, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631529
8.
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.
Bioorg Med Chem Lett
; 18(2): 688-93, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18061451
9.
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
J Med Chem
; 61(17): 7767-7784, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30091920
10.
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
J Med Chem
; 59(1): 431-47, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652588
11.
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430).
J Med Chem
; 59(15): 7252-67, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411843
12.
AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia.
Mol Cancer Ther
; 14(2): 375-83, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487917
13.
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
J Med Chem
; 58(1): 480-511, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469863
14.
Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB.
Oncotarget
; 5(12): 4554-66, 2014 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980832
15.
Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.
Mol Cancer Ther
; 13(4): 880-9, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24526162
16.
Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
J Med Chem
; 57(24): 10499-511, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25384157
17.
Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
J Med Chem
; 57(6): 2472-88, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24548297
18.
Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.
J Med Chem
; 57(7): 2963-88, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24601644
19.
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J Med Chem
; 57(8): 3430-49, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24641103
20.
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
J Med Chem
; 57(4): 1454-72, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24456472