Detalhe da pesquisa
1.
Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies.
Handb Exp Pharmacol
; 257: 147-162, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31595415
2.
Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain.
J Pharmacol Exp Ther
; 361(1): 190-197, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138041
3.
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists.
Bioorg Med Chem Lett
; 25(19): 4158-63, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26299349
4.
Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor ß ligand.
Proc Natl Acad Sci U S A
; 109(5): 1708-12, 2012 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22307635
5.
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Int J Neuropsychopharmacol
; 18(2)2014 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25637376
6.
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Bioorg Med Chem Lett
; 23(5): 1249-52, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374867
7.
Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.
Radiat Res
; 199(5): 468-489, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014943
8.
Muscarinic mechanisms in psychotic disorders.
Handb Exp Pharmacol
; (213): 233-65, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23027418
9.
Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy.
Neurobiol Aging
; 109: 52-63, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34655981
10.
Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice.
Adv Drug Alcohol Res
; 2: 10848, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-38390615
11.
Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species.
J Alzheimers Dis Rep
; 6(1): 1-15, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35243208
12.
Bassoon contributes to tau-seed propagation and neurotoxicity.
Nat Neurosci
; 25(12): 1597-1607, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36344699
13.
Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist.
J Pharmacol Exp Ther
; 338(2): 622-32, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21558436
14.
The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain.
Neuropsychopharmacology
; 46(6): 1194-1206, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33342996
15.
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
J Med Chem
; 64(12): 8076-8100, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081466
16.
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
Int J Neuropsychopharmacol
; 13(8): 1021-33, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20569520
17.
In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268).
J Pharmacol Exp Ther
; 331(3): 1126-36, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19755662
18.
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.
J Neurosci
; 27(10): 2718-26, 2007 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17344409
19.
Autonomic activation associated with ethanol self-administration in adult female P rats.
Pharmacol Biochem Behav
; 91(2): 223-32, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18713644
20.
Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats.
Pain
; 159(7): 1403-1412, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29578947