1.
Bioorg Med Chem Lett
; 18(9): 2860-4, 2008 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18420409
RESUMO
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.