Anesthetic efficacy of 3 volumes of lidocaine with epinephrine in maxillary infiltration anesthesia.

The objective of this randomized double-blind investigation was to compare the anesthetic efficacy and injection discomfort of 3 volumes of 2% lidocaine with 1:100,000 epinephrine for maxillary infiltration anesthesia. A total of 25 subjects received 0.6, 0.9, and 1.2 mL of the anesthetic buccal to an upper canine. Test teeth were assessed with electrical stimulation to determine onset and duration of pulpal anesthesia; soft tissue anesthesia and injection discomfort were assessed by pin-prick test and visual analog scale (VAS). Data were analyzed by 2-way analysis of variance (ANOVA), Friedman, and chi-square tests (alpha = 5%). The 1.2 mL dose induced faster onset of pulpal anesthesia, a higher success rate, and a longer duration of soft tissue/pulpal anesthesia than were achieved with the other doses (P < .05). No differences in injection discomfort were observed between treatments. It is concluded that maxillary infiltration anesthesia with lidocaine and epinephrine has a faster onset, a greater success rate, and a longer duration when a volume of 1.2 mL is used than when volumes less than 1.0 mL are used.

Speed of injection influences efficacy of inferior alveolar nerve blocks: a double-blind randomized controlled trial in volunteers.

This randomized double-blind crossover trial investigated the efficacy and discomfort associated with slow (60 seconds) and rapid (15 seconds) inferior alveolar nerve blocks (IANB) using 2.0 ml of 2% lidocaine with 1:80,000 epinephrine in securing mandibular first molar, premolar and lateral incisor pulp anesthesia in 38 healthy adult volunteers. Episodes of maximal stimulation (80 microA) without sensation on electronic pulp testing were recorded. Injection discomfort was self-recorded by volunteers on 100 mm visual analogue scales. Data were analyzed by McNemar, Friedman, Wilcoxon Signed Ranks, and paired t tests. Slow IANB produced more episodes of no response to maximal pulp stimulation than rapid IANB in molars (220 episodes versus 159, p < 0.001), premolars (253 episodes versus 216, p = 0.003) and lateral incisors (119 episodes versus 99, p = 0.049). Slow IANB was more comfortable than rapid IANB (p = 0.021).

Articaine and lidocaine mandibular buccal infiltration anesthesia: a prospective randomized double-blind cross-over study.

This randomized crossover double-blind trial compared the efficacy of buccal infiltration with 4% articaine and 2% lidocaine (both with 1:100,000 epinephrine) in securing mandibular first molar pulp anesthesia. Injections were given at least 1 week apart in 31 healthy adult volunteers. Electronic pulp testing was undertaken at baseline and at 2 minute intervals until 30 minutes postinjection. A successful outcome was recorded in the absence of pulp sensation on two consecutive maximal pulp tester stimulations (80 muA). 64.5% of articaine and 38.7% of lidocaine infiltrations were successful (p = 0.008). Articaine infiltration produced significantly more episodes of no response to maximum stimulation in first molars than lidocaine (236 and 129, respectively, p < 0.001). Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. Both injections were associated with mild discomfort.

Antimicrobial resistance of Staphylococcus aureus and oral streptococci strains from high-risk endocarditis patients.

This study sought to determine the antimicrobial susceptibility of Staphylcoccus aureus and viridans group streptococci strains collected from the forearm skin and saliva of 30 patients at high risk of endocarditis. Agar susceptibility tests of antibiotics routinely utilized in dentistry were used to verify antimicrobial resistance of bacterial strains. Of the Staphylcoccus aureus strains, 50% were resistant to ampicillin, 53.3% to amoxicillin, 60.0% to penicillin G, 13.3% to amoxicillin/clavulanate, 20.0% to azithromycin, 27.6% to clarithromycin, 23.3% to erythromycin, 3.3% to cefazolin, and 6.7% to clindamycin. Regarding streptococci, 16.7% of the strains were resistant to ampicillin, 16.7% to amoxicillin, 23.3% to azithromycin, 23.3% to clarithromycin, 30.0% to erythromycin, 13.3% to cefazolin, 26.7% to clindamycin, 16.7% to penicillin G, and 3.3% to amoxicillin/clavulanate. Pathogens associated with bacterial endocarditis exhibited elevated resistance rates against the antibiotics used for prophylaxis in dentistry.

Articaine (4%) with epinephrine (1:100,000 or 1:200,000) in intraosseous injections in symptomatic irreversible pulpitis of mandibular molars: anesthetic efficacy and cardiovascular effects.

OBJECTIVE: The aim of this study was to compare the cardiovascular effects and the anesthetic efficacy of intraosseous injections of 4% articaine with 1:100,000 epinephrine (EPI100) or 4% articaine with 1:200,000 epinephrine (EPI200). STUDY DESIGN: In this prospective, randomized, double-blind study, 0.9 mL EPI100 and EPI200 solutions were administered for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis in 60 patients. The anesthetic success and pain during anesthesia were evaluated by visual analog scale. The cardiovascular parameters evaluated were heart rate, diastolic/systolic blood pressure, pulse oximetry, and electrocardiogram changes. RESULTS: Both solutions provided high anesthetic efficacy (96.8% and 93.1% for EPI100 and EPI200, respectively; P > .05), and the cardiovascular parameters showed minimal incidences of significant differences throughout the clinical procedure. CONCLUSIONS: The epinephrine concentration did not affect the efficacy of 4% articaine, and both solutions produced a high success level of pulpal anesthesia. Intraosseous delivery by slow speed of injection did not induce significant clinical changes in cardiovascular parameters.

A prospective randomized trial of different supplementary local anesthetic techniques after failure of inferior alveolar nerve block in patients with irreversible pulpitis in mandibular teeth.

OBJECTIVE: The objective of this study was to compare the efficacy of supplementary repeat inferior alveolar nerve block with 2% lidocaine and epinephrine, buccal infiltration with 4% articaine with epinephrine, intraligamentary injection, or intraosseous injection (both with 2% lidocaine with epinephrine) after failed inferior alveolar nerve block (IANB) for securing pain-free treatment in patients experiencing irreversible pulpitis in mandibular permanent teeth. METHODS: This randomized clinical trial included 182 patients diagnosed with irreversible pulpitis in mandibular teeth. Patients received 2.0 mL of 2% lidocaine with 1:80,000 epinephrine as an IANB injection. Patients who did not experience pain-free treatment received randomly 1 of 4 supplementary techniques, namely repeat lidocaine IANB (rIANB), articaine buccal infiltration (ABI), lidocaine intraligamentary injection (PDL), or lidocaine intraosseous injection (IO). Successful pulp anesthesia was considered to have occurred when no response was obtained to the maximum stimulation (80 reading) of the pulp tester, at which time treatment commenced. Treatment was regarded as being successfully completed when it was associated with no pain. Data were analyzed by χ(2) and Fisher exact tests. RESULTS: Of the 182 patients, 122 achieved successful pulpal anesthesia within 10 minutes after initial IANB injection; 82 experienced pain-free treatment. ABI and IO allowed more successful (pain-free) treatment (84% and 68%, respectively) than rIANB or PDL supplementary techniques (32% and 48%, respectively); this was statistically significant (P = .001). CONCLUSIONS: IANB injection alone does not always allow pain-free treatment for mandibular teeth with irreversible pulpitis. Supplementary buccal infiltration with 4% articaine with epinephrine and intraosseous injection with 2% lidocaine with epinephrine are more likely to allow pain-free treatment than intraligamentary and repeat IANB injections with 2% lidocaine with epinephrine for patients experiencing irreversible pulpitis in mandibular permanent teeth.

Avaliação do desconforto palatal após diferentes técnicas de infiltração vestibular de articaína na maxila / Evaluation of palatal discomfort after different techniques of buccal infiltration of articaine in the maxilla

Objetivo: Comparar o efeito anestésico da infiltração vestibular maxilar (IVM) e do bloqueio do nervo alveolar superior posterior (BNASP) usando articaína 4% com adrenalina 1:100.000 no desconforto na mucosa palatal averiguado pelo teste pin-prick. Método: Neste estudo randomizado, duplo-cego e cruzado foram selecionados 30 voluntários saudáveis os quais foram submetidos a duas diferentes técnicas anestésicas no vestíbulo da maxila (IVM e BNASP) usando articaína 4% com adrenalina 1:100.000. As injeções foram administradas pelo mesmo operador em duas sessões distintas com intervalo de uma semana entre elas. A anestesia dos tecidos moles do palato foi avaliada pelo teste pin-pick com uma agulha 30G por um operador cego para o tipo de injeção. O desconforto da picada de agulha foi avaliado em quatro momentos utilizando uma escala visual analógica (EVA) de 100 mm. Os dados da EVA foram categorizados como: nenhuma dor a dor leve (0-30 mm) e dor moderada a grave (maior que 30 mm). Os dados foram analisados pelo teste Qui-quadrado e os resultados foram estatisticamente significativos quando p menor que 0,05. Resultados: Apesar de ambas as técnicas puderem insensibilizar o palato, a técnica IVM é menos funcional que a técnica BNASP na insensibilização palatal, não atingindo os mesmos objetivos num mesmo intervalo de tempo. O bloqueio do nervo alveolar superior posterior se mostrou mais efetivo na insensibilização do palato aos 5 minutos (p menor que 0,001) enquanto não houve diferença estatisticamente significante aos 10 minutos (p = 0,87). Conclusões: O BNASP com articaína 4% e adrenalina 1:100.000 foi mais eficaz que o IVM na redução do desconforto pin-prick do tecido mole do palato, aos cinco minutos pós-injeção. Ambas as técnicas foram igualmente eficazes em dez minutos.

Objective: To compare the effect of maxillary buccal infiltration (BI) and posterior superior alveolar nerve block (PSANB) using 4% articaine with 1:100,000 epinephrine on pin-prick discomfort on palatal mucosa. Methods: Thirty healthy subjects participated in this double-blind cross-over study. Each subject received two different maxillary buccal anesthetic techniques with 4% articaine with 1:100.000 epinephrine, namely BI and PSANB. Injections were given by the same operator in different sessions with 1-week interval between them. Anesthesia of palatal soft tissue was assessed by the pin-pick test with a 30G needle by an operator blinded to the type of injection. Discomfort of pin-prick was assessed at four time points using a 100 mm visual analogue scale (VAS). Data from the VAS were categorized as none to mild pain (0-30 mm) and moderate to severe pain (greater than 30 mm). Data were analyzed by Chi-square test and the results were statistically significant when p less than 0.05. Results: Although both techniques could numb the palate, the BI technique appeared less functional that the PSANB technique, not reaching the same goals in the same time interval. PSANB was more effective in stunning the palate at 5 minutes (p less than 0.001) while there was no statistically significant difference between the techniques at 10 minutes (p = 0.87). Conclusions: PSANB with 4% articaine and 1:100,000 epinephrine was more effective than BI in reducing pin-prick discomfort of palatal soft tissue at 5 minutes post-injection. Both techniques were equally effective at 10 minutes.