Detalhe da pesquisa
1.
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aß42:Aß40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
J Neurosci
; 40(9): 1956-1974, 2020 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980586
2.
Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.
J Neurosci
; 34(24): 8277-88, 2014 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24920631
3.
A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
J Neurosci
; 34(19): 6425-37, 2014 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24806669
4.
Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease.
Nat Neurosci
; 26(3): 430-446, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36732642
5.
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release.
Nat Commun
; 14(1): 6322, 2023 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37813836
6.
TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models.
iScience
; 26(11): 108362, 2023 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37965143
7.
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.
Clin Pharmacol Ther
; 111(4): 826-834, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064573
8.
TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.
Cell Rep
; 37(13): 110158, 2021 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34965428
9.
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by ß-amyloid pathology.
Neuron
; 109(8): 1283-1301.e6, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33675684
10.
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.
J Neurosci
; 29(7): 1977-86, 2009 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19228952
11.
Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1G93A mouse model of ALS.
Sci Rep
; 10(1): 15713, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32973290
12.
Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.
J Neurosci
; 28(19): 5007-17, 2008 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18463254
13.
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aß.
Alzheimers Res Ther
; 11(1): 97, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31787113
14.
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Cell Rep
; 28(8): 2111-2123.e6, 2019 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31433986
15.
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Neuron
; 100(6): 1322-1336.e7, 2018 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30392797
16.
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models.
Cell Rep
; 22(3): 832-847, 2018 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29346778
17.
BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Sci Rep
; 7: 44249, 2017 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28281673
18.
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
J Med Chem
; 60(19): 8083-8102, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28929759
19.
Widespread brain distribution and activity following i.c.v. infusion of anti-ß-secretase (BACE1) in nonhuman primates.
Br J Pharmacol
; 174(22): 4173-4185, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28859225
20.
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Sci Transl Med
; 9(403)2017 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28814543