The ACE1 Electrical Impedance Tomography System for Thoracic Imaging.

The design and performance of the ACE1 (Active Complex Electrode) electrical impedance tomography system for single-ended phasic voltage measurements is presented. The design of the hardware and calibration procedures allow for reconstruction of conductivity and permittivity images. Phase measurement is achieved with the ACE1 active electrode circuit which measures the amplitude and phase of the voltage and the applied current at the location at which current is injected into the body. An evaluation of the system performance under typical operating conditions includes details of demodulation and calibration and an in-depth look at insightful metrics, such as signal-to-noise ratio variations during a single current pattern. Static and dynamic images of conductivity and permittivity are presented from ACE1 data collected on tank phantoms and human subjects to illustrate the system's utility.

Using injury cost functions from a predictive single-compartment model to assess the severity of mechanical ventilator-induced lung injuries.

Identifying safe ventilation patterns for patients with acute respiratory distress syndrome remains challenging because of the delicate balance between gas exchange and selection of ventilator settings to prevent further ventilator-induced lung injury (VILI). Accordingly, this work seeks to link ventilator settings to graded levels of VILI to identify injury cost functions that predict injury by using a computational model to process pressures and flows measured at the airway opening. Pressure-volume loops were acquired over the course of ~2 h of mechanical ventilation in four different groups of BALB/c mice. A cohort of these animals were subjected to an injurious bronchoalveolar lavage before ventilation. The data were analyzed with a single-compartment model that predicts recruitment/derecruitment and tissue distension at each time step in measured pressure-volume loops. We compared several injury cost functions to markers of VILI-induced blood-gas barrier disruption. Of the cost functions considered, we conclude that mechanical power dissipation and strain heterogeneity are the best at distinguishing between graded levels of injury and are good candidates for forecasting the development of VILI. NEW & NOTEWORTHY This work uses a predictive single-compartment model and injury cost functions to assess graded levels of mechanical ventilator-induced lung injury. The most promising measures include strain heterogeneity and mechanical power dissipation.

Real-Time Implementation of Calderón's Method on Subject-Specific Domains.

A real-time implementation of Calderón's method for the reconstruction of a 2-D conductivity from electrical impedance tomography data is presented, in which domain-specific modeling is taken into account. This is the first implementation of Calderón's method that accounts for correct modeling of non-symmetric domain boundaries in image reconstruction. The domain-specific Calderón's method is derived and reconstructions from experimental tank data are presented, quantifying the distortion when correct modeling is not included in the reconstruction algorithm. Reconstructions from human subject volunteers are presented, demonstrating the method's effectiveness for imaging changes due to ventilation and perfusion in the human thorax.

The ACE1 thoracic Electrical Impedance Tomography system for ventilation and perfusion.

Electrical Impedance Tomography (EIT) is a technique which can image the varying electrical properties of biological tissues. For clinical use of EIT, it can be advantageous to know both tissue conductivity and permittivity. Presented is the hardware design for the pairwise current injection active complex electrode (ACE1) EIT system which measures phasic voltages for conductivity and permittivity image reconstruction. In this system, alternating current is injected on electrodes on the boundary of a domain and single-ended voltage measurements are used in image reconstructions of the domain's interior and in calculating the current applied at the electrodes.