Detalhe da pesquisa
1.
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg Med Chem Lett
; 27(18): 4370-4376, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830649
2.
Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process.
Xenobiotica
; 41(12): 1076-87, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21864203
3.
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
J Med Chem
; 56(11): 4521-36, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668484
4.
Lead identification of novel and selective TYK2 inhibitors.
Eur J Med Chem
; 67: 175-87, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867602
5.
Determination of loperamide in mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis.
Arch Pharm Res
; 34(11): 1983-8, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22139698