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1.
Colorectal Dis ; 20(10): 923-930, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-29706003

RESUMO

AIM: The aim of this study was to investigate risk factors for anastomotic stenosis in patients operated on for diverticular disease. Histological inflammation and diverticula at the resection margins were also considered. METHOD: Patients' characteristics, the surgical technique and postoperative complications were collected from the medical records. Anastomotic stenoses were evaluated prospectively by rigid sigmoidoscopy during follow-up examination. Histological specimens were examined by a single pathologist who investigated inflammation and diverticula at the resection margins. Twenty patients with anastomotic colorectal stenosis from a single tertiary centre were compared with 24 consecutive patients without stenosis. They were all operated on for diverticular disease over a specified time period. RESULTS: Histological inflammation and diverticula were found in 25% and 30% of the resection margins respectively. Univariate analysis showed that age > 71 years (P = 0.0002), female gender (P = 0.0069) and anastomoses located below 12 cm from the anal verge (P = 0.020) were risk factors for stenosis. No correlation was found between anastomotic stenosis and the presence of histological inflammation or diverticula at the resection margins. By multivariate analysis, only age > 71 years was found to be a statistically significant risk factor for stenosis (P = 0.0003, OR = 60.8, 95% CI: 6.4-575.5). CONCLUSION: Anastomotic stenosis is a frequent, long-term complication following surgery for diverticular disease. An analysis demonstrated that age is a risk factor for colorectal stenosis and that histological inflammation and the presence of diverticula near/at the resection margins have no effect on the incidence of stenosis.


Assuntos
Colo/cirurgia , Doenças Diverticulares/cirurgia , Reto/cirurgia , Estomas Cirúrgicos/efeitos adversos , Adulto , Idoso , Anastomose Cirúrgica/efeitos adversos , Constrição Patológica/etiologia , Constrição Patológica/patologia , Feminino , Humanos , Inflamação , Masculino , Margens de Excisão , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Fatores de Risco , Estomas Cirúrgicos/patologia , Adulto Jovem
2.
Dis Esophagus ; 31(5)2018 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-29211841

RESUMO

Surgery for esophageal cancer is a highly stressful and painful procedure, and a significant amount of analgesics may be required to eliminate perioperative pain and blunt the stress response to surgery. Proper management of postoperative pain has invariably been shown to reduce the incidence of postoperative complications and accelerate recovery. Neuraxial analgesic techniques after major thoracic and upper abdominal surgery have long been established to reduce respiratory, cardiovascular, metabolic, inflammatory, and neurohormonal complications.The aim of this review is to evaluate and discuss the relevant clinical benefits and outcome, as well as the possibilities and limits of thoracic epidural anesthesia/analgesia (TEA) in the setting of esophageal resections. A comprehensive search of original articles was conducted investigating relevant literature on MEDLINE, Cochrane reviews, Google Scholar, PubMed, and EMBASE from 1985 to July2017. The relationship between TEA and important endpoints such as the quality of postoperative pain control, postoperative respiratory complications, surgical stress-induced immunosuppression, the overall postoperative morbidity, length of hospital stay, and major outcomes has been explored and reported. TEA has proven to enable patients to mobilize faster, cooperate comfortably with respiratory physiotherapists and achieve satisfactory postoperative lung functions more rapidly. The superior analgesia provided by thoracic epidurals compared to that from parenteral opioids may decrease the incidence of ineffective cough, atelectasis and pulmonary infections, while the associated sympathetic block has been shown to enhance bowel blood flow, prevent reductions in gastric conduit perfusion, and reduce the duration of ileus. Epidural anesthesia/analgesia is still commonly used for major 'open' esophageal surgery, and the recognized advantages in this setting are soundly established, in particular as regards the early recovery from anesthesia, the quality of postoperative pain control, and the significantly shorter duration of postoperative mechanical ventilation. However, this technique requires specific technical skills for an optimal conduction and is not devoid of risks, complications, and failures.


Assuntos
Analgesia Epidural/métodos , Anestesia Epidural/métodos , Neoplasias Esofágicas/cirurgia , Esofagectomia/efeitos adversos , Dor Pós-Operatória/prevenção & controle , Esofagectomia/métodos , Humanos , Manejo da Dor/métodos , Resultado do Tratamento
3.
Dis Esophagus ; 30(10): 1-8, 2017 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-28859392

RESUMO

Wireless pH monitoring of the esophagus has been widely used to detect GERD for more than a decade. It is generally well tolerated and accepted by patients, but it is still unclear whether prolonging a recording beyond the usual 48 hours can improve the test's diagnostic value. The aim of this study is to examine the diagnostic yield of 96-hour pH monitoring vis-à-vis 24- and 48-hour tests, and to ascertain whether any gain in diagnostic terms was of genuine clinical utility. Patients with suspected GERD underwent 4-day PPI-off wireless pH monitoring of the distal esophagus. The capsule was inserted under endoscopic control, 6 cm above the squamocolumnar junction. Average acid exposure time was calculated after 24, 48, and 96 hours of recording. Ninety-nine patients completed the 96 hour test, and formed the study sample. The wireless test method was used in 42 patients (42.4%) unable to tolerate the traditional pH-monitoring catheter, and in 57 (57.6%) with a previous negative pH study despite symptoms suggestive of GERD. On complete analysis, 47 patients (47.5%) had a pathological test result: 19 patients within the first 24 hours (19.2%, 24 hour group); another 16 after 48 hours (+16.2%, 48 hour group), and a further 12 (+12.1%, 96 hour group) only after 96 hours of monitoring. All 47 patients with an abnormal acid exposure were offered and accepted surgery (10 patients) or medical therapy (37 patients). Clinical follow-up was obtained in all patients with a positive Bravo test result after a median 67 months (IQR: 38-98) using a validated symptom questionnaire. A good outcome after fundoplication or medical therapy was achieved in 73.7% of patients in the 24 hour group, in 62.5% of those in the 48 hour group, and in only 25% of those in the 96 hour group, P = 0.02. Long-term wireless pH monitoring enables an increase in the diagnostic yield over traditional 24- and 48-hour pH studies, but prolonging the test may constitute an unwanted bias and prompt the recruitment of more complex patients, in whom the outcome of surgical or medical therapy may prove less than satisfactory. These findings should be taken into account when establishing the guidelines for assessing GERD with such long-term pH monitoring methods.


Assuntos
Monitoramento do pH Esofágico/métodos , Refluxo Gastroesofágico/diagnóstico , Refluxo Gastroesofágico/terapia , Adulto , Monitoramento do pH Esofágico/instrumentação , Feminino , Seguimentos , Fundoplicatura , Refluxo Gastroesofágico/fisiopatologia , Humanos , Masculino , Manometria , Pessoa de Meia-Idade , Estudos Prospectivos , Inibidores da Bomba de Prótons/uso terapêutico , Inquéritos e Questionários , Avaliação de Sintomas , Fatores de Tempo , Resultado do Tratamento , Tecnologia sem Fio
5.
Minerva Chir ; 70(2): 131-9, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25645113

RESUMO

Although rare, metastases to the pancreas from other primary tumors are increasingly recognized in clinical practice, but the optimal treatment remains unclear. When a careful staging is performed and widespread disease is excluded, the indication of pancreatectomy may arise. This study was designated to review the published literature on the results of surgical treatment for the most common malignancies metastasizing to the pancreas. Analysis of the reports show that resection can be performed safely, but long term survival is substantially influenced by the tumor's biology. There are convincing evidences that pancreatic resection for metastasis from renal cell cancer may offer excellent results in term of prolonged survival, while for other type of cancer, pancreatic resection should be considered only a palliative procedure, with only anedoctical reported long-term survivors. So, comparison of the results of surgical and non-surgical management of metastatic tumors to the pancreas is very difficult to perform. There is a need of studies evaluating the role of chemotherapy in the neoadjuvant setting or the best sequential use of multimodality treatment (targeted therapy, radiotherapy, surgery, etc.). At the moment, pancreatic resection for metastasis should be reserved to patients in good health conditions, with isolated disease from renal cell cancer. For other types of tumor, surgery should be performed only in individual basis.


Assuntos
Carcinoma de Células Renais/secundário , Carcinoma de Células Renais/terapia , Neoplasias Renais/patologia , Neoplasias Renais/terapia , Neoplasias Pancreáticas/secundário , Neoplasias Pancreáticas/terapia , Carcinoma de Células Renais/diagnóstico , Carcinoma de Células Renais/mortalidade , Terapia Combinada/métodos , Medicina Baseada em Evidências , Humanos , Imunoterapia/efeitos adversos , Imunoterapia/métodos , Neoplasias Renais/diagnóstico , Neoplasias Renais/mortalidade , Estadiamento de Neoplasias , Pancreatectomia/métodos , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/mortalidade , Prognóstico , Análise de Sobrevida , Resultado do Tratamento
6.
Colorectal Dis ; 16(10): O367-9, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24916474

RESUMO

AIM: An ileorectal bypass performed entirely through a transanal route has recently been described in an animal model. The present study aimed to demonstrate its technical feasibility in four human cadavers. METHOD: A transanal endoscopic microsurgery (TEM) device and endoscopic instruments were used. The principal steps of the procedure included insertion of the TEM device, rectostomy above the peritoneal reflection, peritoneoscopy using a standard gastroscope and delivery of the small bowel through the proctostomy to perform an anastomosis. RESULTS: The procedure was successfully completed using transanal access in all cases. The mean procedure time was 90 min. The bypass was patent, and the anastomosis between the intraperitoneal rectum and the terminal ileum was leakproof. CONCLUSION: Transanal ileoproctostomy is technically feasible in human cadavers. The procedure may become an alternative to stoma formation in selected patients with colonic obstruction.


Assuntos
Endoscopia Gastrointestinal/métodos , Íleo/cirurgia , Cirurgia Endoscópica por Orifício Natural/métodos , Reto/cirurgia , Idoso , Idoso de 80 Anos ou mais , Canal Anal , Anastomose Cirúrgica/métodos , Cadáver , Endoscopia Gastrointestinal/instrumentação , Estudos de Viabilidade , Feminino , Humanos , Masculino , Microcirurgia/instrumentação , Pessoa de Meia-Idade , Cirurgia Endoscópica por Orifício Natural/instrumentação
7.
Colorectal Dis ; 14(3): e124-8, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21910814

RESUMO

AIM: The aim of the study was to analyse the incidence of benign colorectal anastomotic stenoses in consecutive patients operated on in a single institution and to assess risk factors for their development. Their impact on quality of life was also evaluated. METHOD: Patient characteristics, indications for surgery, surgical technique and postoperative complications were prospectively recorded. Stenosis was evaluated by rectoscopy at regular intervals, and patients were treated only if symptomatic. After at least 6 months following surgery, patients were asked to respond to the Short Form 36-item quality-of-life questionnaire during a telephone interview. RESULTS: Of the original 211 patients considered, 195 underwent a follow-up rectoscopy and were included in the study. Benign stenosis were found in 26 (13%), and 19 (73%) symptomatic patients were treated successfully (15 with endoscopic dilatation and four with radial diathermic surgical incisions). Risk factors for anastomotic stenosis according to univariate analysis were female sex, diverticulitis, mechanical anastomosis, and anastomosis located between 8 and 12 cm from the anal verge. The significant risk factors identified by multivariate analysis were diverticulitis (OR 5, P=0.002) and mechanical anastomosis (OR 9, P=0.04). The self-perceived quality of life of patients with stenosis was significantly worse compared with controls. CONCLUSION: Since diverticulitis and mechanical anastomosis are risk factors for anastomotic stenosis, surgeons should take this into account when they are considering what type of anastomotic technique to utilize.


Assuntos
Colo/cirurgia , Doenças do Colo/etiologia , Complicações Pós-Operatórias/etiologia , Qualidade de Vida , Doenças Retais/etiologia , Reto/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anastomose Cirúrgica , Colectomia , Doenças do Colo/diagnóstico , Doenças do Colo/epidemiologia , Doenças do Colo/terapia , Constrição Patológica/epidemiologia , Constrição Patológica/etiologia , Feminino , Seguimentos , Humanos , Incidência , Laparoscopia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/terapia , Estudos Prospectivos , Doenças Retais/diagnóstico , Doenças Retais/epidemiologia , Doenças Retais/terapia , Fatores de Risco , Inquéritos e Questionários
8.
Dis Esophagus ; 24(8): E41-4, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21951866

RESUMO

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis. While its incidence is unknown, approximately 300 cases have been reported in the literature. The syndrome typically presents with a characteristic facial rash (poikiloderma), its diagnostic hallmark, and heterogeneous clinical features including congenital skeletal abnormalities, sparse hair distribution, juvenile cataracts, and a predisposition to osteosarcoma. Gastrointestinal symptoms, such as pyloric stenosis, anal atresia, annular pancreas, and rectovaginal fistula, have also been reported sporadically. This is a report describing a patient diagnosed with RTS referred to us because of dysphagia caused by esophageal stenosis. Long-term results of endoscopic dilation are also presented.


Assuntos
Cateterismo , Estenose Esofágica/complicações , Estenose Esofágica/terapia , Síndrome de Rothmund-Thomson/complicações , Adolescente , Adulto , Estenose Esofágica/patologia , Feminino , Humanos , Hipotireoidismo/complicações , Hipotireoidismo/tratamento farmacológico , Lactente , Adulto Jovem
9.
Colorectal Dis ; 12(7 Online): e128-34, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19508521

RESUMO

OBJECTIVE: To evaluate the clinical course of extensive anal condylomatosis in relation to treatment modalities, patient comorbidity and immune function, and associated papillomavirus (HPV) sequences. METHOD: Clinical data, treatment modalities and follow-up were recorded and analysed in relation to host and viral type. Histology, immunohistochemistry and molecular analyses for HPV search and typing were performed on formalin-fixed paraffin-embedded samples. RESULTS: Sixteen patients [14 males, median age 41.8 years (range 19-66)] affected by extensive anal condylomatosis [10 Buschke-Lowenstein Tumors (BLT) and 6 condylomatosis] treated in three different Italian institutions were included. There was associated preoperative anal intraepithelial neoplasia grade 3 (AIN3) in one and invasive carcinoma in three patients. After radical resection (n = 16) recurrence occurred in 4/10 (40%) BLT patients. Malignancy before or after treatment developed in 5/16 (31.25%) patients. HPV sequences were present in all the samples of 15 evaluable patients (types 6 or 11, 9 patients; type 16, 6 patients). A statistically significant association was found between presence of HPV type 16 and both malignancy and recurrence. Viral variant L83V was present in 3/4 HPV 16 positive recurrent cases. CONCLUSION: Radical resection resulted in a favourable clinical course. Typing of HPV sequences in the management of patients affected by extensive anal condylomatosis may be useful.


Assuntos
Colectomia/métodos , Condiloma Acuminado/virologia , DNA Viral/análise , HIV/genética , Vírus de Hepatite/genética , Proctite/virologia , Adulto , Idoso , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/cirurgia , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Proctite/diagnóstico , Proctite/cirurgia , Prognóstico , Estudos Retrospectivos , Adulto Jovem
10.
Hernia ; 24(1): 57-65, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-30661179

RESUMO

PURPOSE: The advantages of biological meshes for ventral hernia repair are still under debate. Given the high financial cost, the proper indications for biological meshes should be clarified to restrict their use to properly selected patients. METHODS: A retrospective database was instituted to register all cases of abdominal wall defect treated with biological meshes from 1/2010 to 3/2016. RESULTS: A total of 227 patients (mean age: 64 years) whose ventral abdominal defects were reconstructed with a biological mesh were included in the study. Patients were divided according to the 2010 four-level surgical-site complication risk grading system proposed by the Ventral Hernia Working Group (VHWG): Grade 1 (G1, 12 cases), Grade 2 (G2, 68 cases), Grade 3 (G3, 112 cases), and Grade 4 (G4, 35 cases). The surgical site complication rate was higher in patients with one or more risk factors (33.6% vs 19% in patients with no risk factors) (P = 0.68). Statistically significant risk factors associated with the onset of one or more postoperative surgical site complications included: diabetes, coronary artery disease, immunosuppression, and obesity. Recurrence was more common in patients with surgical site complications and mainly associated with infection (38.9%) and wound necrosis (44.4%), and in cases of inlay positioning of the mesh (36%). CONCLUSIONS: Due to their high costs, biological mesh should not be used in G1 patients. In infected fields (G4), they should only be used if no other surgical solution is feasible. There is a clear need to prospectively evaluate the performance of biological meshes.


Assuntos
Bioprótese , Hérnia Ventral/cirurgia , Herniorrafia , Telas Cirúrgicas , Adulto , Idoso , Idoso de 80 Anos ou mais , Bases de Dados Factuais , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Recidiva , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
11.
Colorectal Dis ; 10(5): 446-52, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17868407

RESUMO

OBJECTIVE: Colpocystodefecography images the pelvic floor with the dynamics of defecation, but various authors claim that it overestimates clinical findings. The aim of this study was to evaluate the pre- and postoperative consistency between clinical and colpocystodefecographic findings in patients undergoing surgery for obstructed defecation. METHOD Between June 2001 and September 2003, 20 patients underwent transvaginal posterior colpoperineorrhaphy and rectal mucosal prolapsectomy with one circular stapler for symptomatic rectocele and concomitant anorectal prolapse. They were prospectively evaluated both before surgery by designed questionnaire on constipation and incontinence, proctological, gynaecological and urological examinations, colpocystodefecography and anorectal manometry, and after operation at 6 months by questionnaire and a proctological check-up. The mean follow-up was 30 months (24-48 months). RESULTS: At 6 months the questionnaire revealed a major response in terms of symptoms. The proctological visit confirmed the absence of rectocele in 19 (95%) patients, while the anorectal prolapse had completely disappeared in 17 (85%) patients. Postoperative colpocystodefecography demonstrated a general reduction in the dimensions of the rectocele, which had completely disappeared in five (25%) patients; 40% of the patients had a persistent anorectal prolapse. CONCLUSION: Preoperative data analysis showed a statistically significant correlation between clinical and radiological findings. Postoperatively the global clinical assessment correlated well with patient satisfaction, while there was evidence of a statistically significant difference between the radiological and clinical findings. Routine postoperative use of colpocystodefecography is unjustified unless there is clinical evidence of surgical failure.


Assuntos
Defecação/fisiologia , Defecografia , Diafragma da Pelve/diagnóstico por imagem , Prolapso Retal/cirurgia , Retocele/cirurgia , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Satisfação do Paciente , Período Pós-Operatório , Prolapso Retal/diagnóstico por imagem , Retocele/diagnóstico por imagem , Resultado do Tratamento , Bexiga Urinária/diagnóstico por imagem , Útero/anatomia & histologia , Vagina/diagnóstico por imagem
12.
Surg Endosc ; 21(7): 1175-9, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17356942

RESUMO

BACKGROUND: Perioperative nutrition for patients undergoing colon surgery seems to be effective in reducing catabolism and improving immunologic parameters. A relatively low-fiber and highly absorbable diet may facilitate the intestinal cleansing and loop relaxation fundamental for laparoscopic surgery with a lower dose of iso-osmotic laxative. METHODS: From 1 February 2004 to 30 July 2005, 28 patients referred to our unit with colon disease (neoplasms and diverticular disease) amenable to laparoscopic surgery were prospectively randomized into two groups of 14 patients each. For 6 days preoperatively, the patients in group 1 were given 750 ml/day of a diet enriched with arginine, omega-3 fatty acids, and ribonucleic acid (RNA) associated with low-fiber foods. They had 1 day of intestinal preparation with 3 l of iso-osmotic laxative. On postoperative day 2, they were fed orally with the same diet. The patients in group 2 preoperatively received a low-fiber diet. They had 2 days of preparation with iso-osmotic laxative (3 l/day). On postoperative day 3, oral nutrition was restored. Intraoperatively, we evaluated loop relaxation and intestinal cleanliness. Clinical trends were monitored in both groups, as well as adverse reactions to early nutrition. The nutritional (albumin, prealbumin) and immunologic (lymphocyte subpopulations, immunoglobulins) biohumoral parameters were evaluated at the first visit, on the day before surgery, on postoperative day 7, and 1 month after surgery. RESULTS: The two groups did not differ in terms of age, gender, distribution of disease, or baseline anthropometric, biohumoral, or immunologic parameters. There was a significant increase in CD4 lymphocytes on the day before surgery as compared with baseline parameters (p < 0.05) in group 1, but not in group 2. There was no statistically significant difference between the two groups in intestinal loop relaxation or cleanliness or in postoperative infectious complications. CONCLUSIONS: Perioperative immunonutrition proved to be safe and useful in increasing the perioperative immunologic cell response. It may contribute toward improving the preparation and relaxation of the intestinal loops despite the shorter intestinal preparation.


Assuntos
Cirurgia Colorretal/métodos , Nutrição Enteral/métodos , Sistema Imunitário/fisiologia , Assistência Perioperatória/métodos , Idoso , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/imunologia , Neoplasias Colorretais/cirurgia , Divertículo do Colo/diagnóstico , Divertículo do Colo/imunologia , Divertículo do Colo/cirurgia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Necessidades Nutricionais , Estado Nutricional , Complicações Pós-Operatórias/prevenção & controle , Probabilidade , Estudos Prospectivos , Estatísticas não Paramétricas , Resultado do Tratamento
13.
Updates Surg ; 68(2): 199-203, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26951523

RESUMO

Prosthetic mesh rolled up and fixed with stitches like a slim cigarette ("slim-mesh") for laparoscopic ventral hernia (VH) repair is an new technique which allows an easy intraperitoneally introduction, distension and circumferential fixation of a prosthetic mesh without transabdominal fixation sutures even for meshes larger than 16 cm up to 30 cm for the "slim-mesh" repair of wide ventral hernias. We report the technique of laparoscopic repair of VH with "slim-mesh". This technique enables an easy intra-peritoneally introduction of the mesh through the trocar because it reduces consistently its size, it allows a rapid intra-abdominal handling of the mesh and a fast and easy fixation for VH repair. The average time of surgery with "slim-mesh" for treatment of all 28 VH was 97 min ranging from 57 to 160 min. The average time for the repair of the 24 VH smaller than 10 cm was 91 and 135 min for the four VH larger than 10-22 cm. This new surgical technique leads to a reduction of surgical risks avoiding the use of transfascial sutures with the associated complications. This new surgical procedure in our experience is fast, safe, simple and also easily reproducible by surgeons in laparoscopic training. This technique may be used in wide VH (larger than 10-22 cm) that generally require open surgery.


Assuntos
Hérnia Ventral/cirurgia , Herniorrafia/métodos , Laparoscopia/métodos , Telas Cirúrgicas , Humanos , Desenho de Prótese , Técnicas de Sutura
14.
J Visc Surg ; 152(5): 279-84, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26117303

RESUMO

INTRODUCTION: Pancreatic and perampullary neoplasms in patients aged 80 or older trouble the surgeons because of the risk of surgical treatment. We have reviewed our experience and literature's reports of pancreaticoduodenectomy in octogenarians, evaluating early results and long-term survival in pancreatic cancer group. METHODS: Three hundred eighty-five patients who underwent pancreaticoduodenectomy for neoplasms from 1998 to 2011 were included in the study, and were divided in two groups: group 1, patients younger than 80 years of age, and group 2, patients 80 years of age and older. Operative morbidity, mortality, disease-free and long-term survival were analysed. English literature was systematically searched for pancreatic resection's outcome in octogenarians. RESULTS: There were 385 pancreaticoduodenectomies: 362 patients were in group 1 and 23 patients in group 2. There was no significant difference regarding gender, and pathologic findings between the two groups. Complications' rate (40 vs. 43%), mortality rate (4% vs. 0%), and overall median survival for pancreatic cancer patients were not statistically different in the two groups (median 21 vs. 19 months). Literature's review showed 14 reports of pancreatic resection in octogenarians. Most of the studies (particularly in centres with high-volume pancreatic surgery) showed that outcome after pancreatectomy was not different in octogenarians or in younger patients. CONCLUSION: Pancreaticoduodenectomy is an acceptable option for elderly patients. Age alone should not be considered a contraindication to major pancreatic resection, but a careful preoperative evaluation and an accurate postoperative management are mandatory.


Assuntos
Adenocarcinoma/cirurgia , Carcinoma Neuroendócrino/cirurgia , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia , Adenocarcinoma/mortalidade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Carcinoma Neuroendócrino/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/mortalidade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Análise de Sobrevida , Resultado do Tratamento
15.
J Thorac Cardiovasc Surg ; 119(3): 453-7, 2000 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10694603

RESUMO

OBJECTIVE: Postoperative chylothorax remains an uncommon but potentially life-threatening complication of esophagectomy for cancer, and the ideal management is still controversial. The aim of the study was to compare the outcomes of patients treated nonoperatively with those of patients promptly undergoing reoperation. METHODS: From 1980 to 1998, 1787 esophagectomies for esophageal or cardia cancer were performed, and 19 (1.1%) patients had postoperative chylothorax. We analyzed type of operation, surgical approach, delay of diagnosis of chylothorax, daily chest tube output, type of management, major complications, death, hospital stay, and final outcome. RESULTS: Of the 19 patients with chylothorax, 11 were initially managed nonoperatively (group A): 4 (36%) patients had spontaneous resolution of chylothorax, and the other 7 required reoperation for the persistence of a high-volume output. There were three infectious complications and one postoperative death in this group. No reliable predictive criteria of successful versus unsuccessful nonoperative management could be found. The 8 most recent patients underwent early reoperation (group B). All patients recovered, and no major complications possibly related to chylothorax or hospital deaths were observed. They were discharged after a median of 22 days (range, 12-85 days) compared with a median of 36 days (range, 21-64 days) for patients of group A. CONCLUSIONS: Early thoracic duct ligation is the treatment of choice for chylothorax occurring after esophagectomy. Reoperation should be performed immediately after the diagnosis is made to avoid the complications related to nutritional and immunologic depletion caused by prolonged nonoperative treatment.


Assuntos
Quilotórax/etiologia , Quilotórax/cirurgia , Neoplasias Esofágicas/cirurgia , Esofagectomia/efeitos adversos , Ducto Torácico , Adulto , Idoso , Drenagem , Feminino , Humanos , Ligadura , Masculino , Pessoa de Meia-Idade , Nutrição Parenteral Total , Reoperação , Estudos Retrospectivos , Fatores de Tempo
16.
Minerva Med ; 75(39): 2301-4, 1984 Oct 13.
Artigo em Italiano | MEDLINE | ID: mdl-6504393

RESUMO

Prolonged monitoring of oesophageal pH is the most sensitive test for GOR. An ideal instrument for this test should be simple, reliable and inexpensive. It should enable the patient to live a normal life, even at home, allows rapid analysis of the data, and monitors other parameters at the same time (intragastric pH). An instrument with these features has been devised at Padua University Surgical Clinic. It uses NSC 800 microprocessor technology and has a 32 K C-MOS memory. The examination can be programmed (patient code, date, start and end times, sampling duration and time). Postural changes are automatically recorded. Subjective symptoms are signalled by the patient through an alphanumeric keyboard. ROM software at the end of the test is employed for automatic processing according to Johnson and De Meester's parameters. Proxima is also made for a serial output to a larger-capacity computer and an analogue output compatible with a Beckman paper printer.


Assuntos
Esôfago/fisiologia , Monitorização Fisiológica/instrumentação , Humanos , Concentração de Íons de Hidrogênio , Microcomputadores , Fatores de Tempo
17.
Int Surg ; 65(2): 151-5, 1980.
Artigo em Inglês | MEDLINE | ID: mdl-7216658

RESUMO

Arterialization of the hepatic end of the portal vein after portacaval shunt was studied in the rabbit in order to evaluate clinical, metabolic, and histologic modifications compared with portacaval shunt alone. The mortality rate of arterialized rabbits diminished considerably at the 45th postoperative day, preoperative body weight was regained and there was significant liver weight/body weight ratio difference with both sham operated and portacaval shunted rabbits (p less than or equal to 0.001). Furthermore, after arterialization, clinical examination, laboratory liver function tests and pathological studies were all near normal. Arterialization after portacaval shunt appears to be safe when flow through the arterioportal anastomosis is low.


Assuntos
Fígado/irrigação sanguínea , Derivação Portocava Cirúrgica , Veia Porta/cirurgia , Veias Renais/cirurgia , Animais , Fígado/anatomia & histologia , Circulação Hepática , Testes de Função Hepática , Masculino , Tamanho do Órgão , Coelhos
18.
J Med Eng Technol ; 8(5): 221-3, 1984.
Artigo em Inglês | MEDLINE | ID: mdl-6527372

RESUMO

An iridium-iridium oxide electrode for in vivo pH measurement of the distal oesophagus is described. It is small and flexible so it is well accepted by patients for long-term pH monitoring. The electrode also offers the possibility of including another electrode and/or a pressure sensor for simultaneous detection of two or more parameters--gastric pH or oesophageal pressure for example. A clinical study was performed on 15 healthy volunteers and the results were checked on a DGC Nova 4/S computer, showing less than 0.005% of tension in mV out of the established range in a period of 24 h pH monitoring. The volunteers' results were compared with the normal values obtained by DeMeester using a glass electrode on a similar, healthy group of American patients and no significant differences were observed. Owing to its small size, reliability, fast response to pH changes, durability and its easy storage, the Ir/IrO2 electrode is ideal for long-term pH monitoring of the upper gastro-intestinal tract.


Assuntos
Eletrodos , Esôfago/análise , Determinação da Acidez Gástrica/instrumentação , Refluxo Gastroesofágico/diagnóstico , Adolescente , Adulto , Feminino , Humanos , Concentração de Íons de Hidrogênio , Irídio , Masculino
19.
Minerva Chir ; 35(15-16): 1091-6, 1980.
Artigo em Italiano | MEDLINE | ID: mdl-7454043

RESUMO

A new experimental model has been employed as part of research into portosystemic encephalopathy, namely end-to-side portacaval shunt associated wih revascularization of the portal bed with the right renal artery in the rabbit. Study of the changes brought on by the operation is based on the evaluation of survival, the behaviour of the weight curve, the weight liver-body/weight ratio, and the angiographic and histologic pictures. Significant variations were obtained by comparison with animals in which an associated portocaval shunt was performed.


Assuntos
Hipertensão Portal/cirurgia , Derivação Portocava Cirúrgica/métodos , Artéria Renal/cirurgia , Animais , Encefalopatias/prevenção & controle , Fígado/irrigação sanguínea , Derivação Portocava Cirúrgica/efeitos adversos , Complicações Pós-Operatórias/prevenção & controle , Coelhos
20.
Minerva Chir ; 59(3): 301-5, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15252398

RESUMO

Colonic diverticular disease is a benign condition typical of the Western world, but it is not rare for even the 1st episode of diverticulitis to carry potentially fatal complications. The evolution of a peridiverticular process generally poses problems for medical treatment and exposes patients to repeated episodes of diverticulitis, making surgical treatment necessary in approximately 30% of symptomatic patients. One of the most worrying complications of diverticulosis is internal fistula. The most common types of fistula are colovesical and colovaginal, against which the uterus can act as an important protective factor. The symptoms and the clinical and instrumental management of patients with diverticular fistulas are much the same as for patients with episodes of acute diverticulitis. Staging of the disease (according to Hinchey) should be done promptly so that the necessary action can be taken prior to surgery, implementing total parenteral nutrition (TPN), nasogastric aspiration and broad-spectrum antibiotic treatment. The best surgical approach to adopt in patients with diverticulitis complicated by fistula is still not entirely clear, though the 3-step strategy is currently tending to be abandoned due to its high morbidity and mortality rates. There is a widespread conviction, however, that the 2-step strategy (Hartmann, or resection with protective stomy) and the 1-step alternative should be reserved, respectively, for patients in Hinchey stages 3, 4 and 1, 2 with a situation of attenuated local inflammation. The 1-step approach seems to be safe and effective. This report describes a case of colovaginal fistula in a patient with colonic diverticulosis who had recently undergone hysterectomy, but who, unlike such cases in the past, was treated in a single step using a laparoscopic technique.


Assuntos
Doenças do Colo/cirurgia , Divertículo/cirurgia , Fístula Intestinal/cirurgia , Laparoscopia , Fístula Vaginal/cirurgia , Doenças do Colo/complicações , Doenças do Colo/diagnóstico por imagem , Diverticulite/cirurgia , Divertículo/complicações , Divertículo/diagnóstico por imagem , Feminino , Humanos , Histerectomia Vaginal/efeitos adversos , Fístula Intestinal/diagnóstico por imagem , Fístula Intestinal/etiologia , Pessoa de Meia-Idade , Radiografia , Doenças do Colo Sigmoide/diagnóstico por imagem , Doenças do Colo Sigmoide/etiologia , Doenças do Colo Sigmoide/cirurgia , Resultado do Tratamento , Fístula Vaginal/diagnóstico por imagem , Fístula Vaginal/etiologia
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