RESUMO
In the title compound, C18H18N2O, the morpholine ring adopts a chair conformation with the exocyclic N-C bond in an equatorial orientation. The dihedral angles between the central benzene ring and the morpholine ring (all atoms) and the cyano-benzene ring are 87.87â (7) and 52.54â (7)°, respectively. No significant inter-molecular inter-actions are observed in the crystal structure.
RESUMO
In the title compound, C22H18N8·H2O, the dihedral angle between the tetra-zole rings is 69.58â (1)° while the terminal phenyl ring makes dihedral angles of 26.98â (8) and 39.75â (8)° with the other benzene rings. The rings of the biphenyl unit subtend a dihedral angle of 55.23â (8)°. In the crystal, the solvent water mol-ecule is linked to the main mol-ecule via an N-Hâ¯O hydrogen bond. In addition, C-Hâ¯N and O-Hâ¯N hydrogen bonds link the components into chains along [010]. The crystal structure also features C-Hâ¯π and π-π inter-actions, with centroid-centroid distances of 3.6556â (9) and 3.826â (1)â Å.
RESUMO
A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10(-5) concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.
Assuntos
Antineoplásicos/química , Indóis/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Humanos , Indóis/farmacologia , Mutagênicos/química , Mutagênicos/farmacologiaRESUMO
The title compound, C13H13Cl2NO, has a 3-(propan-2-yl-idene)indolin-2-one core with a Cl atom and a chloro-ethyl substituent attached to the aromatic ring. Two atoms of the aromatic ring and the chloro-ethyl substituent atoms are disordered over two sets of sites with a refined occupancy ratio of 0.826â (3):0.174â (3). In the crystal, mol-ecules are linked by pairs of N-Hâ¯O hydrogen bonds, forming inversion dimers with an R 2 (2)(8) ring motif.