Detalhe da pesquisa
1.
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model.
Bioorg Med Chem Lett
; 80: 129108, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36538993
2.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32042197
3.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Bioorg Med Chem Lett
; 60: 128549, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041943
4.
Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.
J Virol
; 90(12): 5759-69, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27053559
5.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35728998
6.
The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein.
J Virol
; 89(5): 2979-84, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25540382
7.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712838
8.
Erratum for Metrick and Heldwein, Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.
J Virol
; 90(15): 7007-7008, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27402813
9.
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
ACS Med Chem Lett
; 13(4): 665-673, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450377
10.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
11.
Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein.
mBio
; 11(3)2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32371601
12.
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
J Med Chem
; 63(21): 12526-12541, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696648