Detalhe da pesquisa
1.
Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
Brain
; 138(Pt 12): 3632-53, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26490331
2.
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.
Neurobiol Dis
; 69: 263-75, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24844147
3.
Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial.
J Transl Med
; 12: 38, 2014 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24507657
4.
Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy.
Neurobiol Dis
; 38(1): 125-35, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20085811
5.
Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy.
J Pharmacol Exp Ther
; 326(2): 623-32, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18492948
6.
TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death.
Pancreas
; 47(1): 18-24, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29200128
7.
TRO40303, a mitochondrial-targeted cytoprotective compound, provides protection in hepatitis models.
Pharmacol Res Perspect
; 3(3): e00144, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26236486
8.
Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease.
PLoS One
; 8(11): e81528, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24303051
9.
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
J Pharmacol Exp Ther
; 322(2): 709-20, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17496168