Detalhe da pesquisa
1.
From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs.
Molecules
; 28(17)2023 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37687158
2.
Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies.
J Chem Inf Model
; 62(16): 3910-3927, 2022 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35948439
3.
Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists.
Molecules
; 28(1)2022 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615465
4.
Treatment with a GSK-3ß/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder.
Int J Mol Sci
; 22(11)2021 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34073043
5.
Transglutaminases, neuronal cell death and neural repair: implications for traumatic brain injury and therapeutics.
Curr Opin Neurol
; 32(6): 796-801, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31577602
6.
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.
J Enzyme Inhib Med Chem
; 34(1): 740-752, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30829081
7.
Overview of the Anticancer Profile of Avenanthramides from Oat.
Int J Mol Sci
; 20(18)2019 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31540249
8.
Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors.
Bioorg Med Chem Lett
; 28(6): 1001-1004, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29496367
9.
Perspectives in Designing Multifunctional Molecules in Antipsychotic Drug Discovery.
Drug Dev Res
; 77(8): 437-443, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27539712
10.
Macrocyclic naphthalene diimides as G-quadruplex binders.
Bioorg Med Chem
; 23(13): 3819-30, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25935290
11.
First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3ß/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer's Disease.
ACS Chem Neurosci
; 15(11): 2099-2111, 2024 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38747979
12.
In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers.
Bioorg Med Chem Lett
; 23(13): 3901-4, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23692871
13.
Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery.
ACS Bio Med Chem Au
; 3(1): 32-45, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37101607
14.
PROTAC-Induced Glycogen Synthase Kinase 3ß Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease.
ACS Chem Neurosci
; 14(11): 1963-1970, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37218653
15.
Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study.
Amino Acids
; 42(2-3): 913-28, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21858471
16.
Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One.
J Med Chem
; 65(14): 9507-9530, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35816671
17.
Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.
Bioorg Med Chem Lett
; 21(9): 2655-8, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21236667
18.
Glycogen Synthase Kinase 3ß: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?
J Med Chem
; 64(1): 26-41, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33346659
19.
Synthetic polyamines: an overview of their multiple biological activities.
Amino Acids
; 38(2): 383-92, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20012115
20.
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer.
Eur J Med Chem
; 202: 112504, 2020 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32712536