RESUMO
The infective factor seems to be very important in the physiopathology of intestinal ischaemia syndrome, as we suggested in previous research works, and is probably responsible for the disturbances observed in pulmonary surfactant. In the present research project, 48 mongrel dogs were studied under different situations of experimental intestinal ischaemia (arterial, venous and revascularization) after laparotomy and the pulmonary surfactant was determined in all cases. We conclude that the observed changes in phospholipids (phosphatidylglycerol and phosphatidylinositol particularly) can be directly related to the infective factor and important enough to induce physicochemical alterations of the surfactant and subsequently pulmonary function.
Assuntos
Intestinos/irrigação sanguínea , Isquemia/fisiopatologia , Surfactantes Pulmonares/metabolismo , Animais , Cães , Oclusão Vascular Mesentérica/fisiopatologia , Fosfatidilgliceróis/metabolismo , Fosfatidilinositóis/metabolismo , Fatores de TempoAssuntos
Injúria Renal Aguda/etiologia , Síndrome de Hiperestimulação Ovariana/complicações , Síndrome do Desconforto Respiratório/etiologia , Aborto Terapêutico , Injúria Renal Aguda/terapia , Adulto , Síndrome de Vazamento Capilar/etiologia , Feminino , Humanos , Metotrexato/uso terapêutico , Síndrome de Hiperestimulação Ovariana/fisiopatologia , Síndrome de Hiperestimulação Ovariana/cirurgia , Gravidez , Complicações na Gravidez/etiologia , Complicações na Gravidez/fisiopatologia , Complicações na Gravidez/cirurgia , Complicações na Gravidez/terapia , Gravidez Ectópica/diagnóstico , Gravidez Ectópica/tratamento farmacológico , Respiração Artificial , Síndrome do Desconforto Respiratório/terapiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Adulto , Injúria Renal Aguda/etiologia , Síndrome de Hiperestimulação Ovariana/complicações , Síndrome do Desconforto Respiratório/etiologia , Aborto Terapêutico , Síndrome de Vazamento Capilar/etiologia , Gravidez Ectópica , Injúria Renal Aguda/terapia , Metotrexato/uso terapêutico , Complicações na Gravidez , Síndrome do Desconforto Respiratório/terapiaRESUMO
Sialidase of influenza virus type A has been extensively studied through structural and kinetic approaches. However, sialidase of influenza virus type B has been less investigated. In this work, we have studied the activity and some properties (optimal pH, KM, Vmax, thermal stability) of sialidase in three influenza virus strains of type B (circulating in the period 1983-86) and also the activity and properties of sialidase from three virus strains of type A circulating at the same period of time. The results show that the activity and the Vmax was always higher for sialidase of type A viruses relative to those values of type B. Differences were also found for optimal pH and, in some cases, for thermal stability of the sialidase between strains belonging to the influenza viruses type A and B. However, the behaviour for the sialidase in all strains was very similar towards two competitive inhibitors. Thus, it could be suggested that the evolution pattern of the sialidase of both types of influenza viruses determines some modifications which result in a higher efficiency for sialidase of some strains of influenza virus type A, but maintaining in the two types of viruses a similar behaviour towards competitive inhibitors.