Detalhe da pesquisa
1.
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).
Bioorg Med Chem Lett
; 30(12): 127198, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32334914
2.
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.
Bioorg Med Chem Lett
; 30(14): 127243, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527545
3.
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Bioorg Med Chem Lett
; 30(23): 127602, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33038544
4.
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Bioorg Med Chem Lett
; 30(12): 127205, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32336498
5.
3-Substituted Quinolines as RORγt Inverse Agonists.
Bioorg Med Chem Lett
; 29(12): 1463-1470, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31010722
6.
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.
Bioorg Med Chem Lett
; 27(9): 2047-2057, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28318945
7.
6-Substituted quinolines as RORγt inverse agonists.
Bioorg Med Chem Lett
; 27(23): 5277-5283, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29079472
8.
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
ACS Med Chem Lett
; 15(4): 486-492, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628796
9.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
J Med Chem
; 65(15): 10419-10440, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862732
10.
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem
; 65(21): 14326-14336, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314537
11.
Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds.
J Steroid Biochem Mol Biol
; 108(1-2): 44-54, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17964775
12.
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
Bioorg Med Chem Lett
; 18(6): 2114-21, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18272363
13.
Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.
Arch Biochem Biophys
; 449(1-2): 47-56, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16620770