Detalhe da pesquisa
1.
Role of Hepatic Stellate and Liver Sinusoidal Endothelial Cells in a Human Primary Cell Three-Dimensional Model of Nonalcoholic Steatohepatitis.
Am J Pathol
; 194(3): 353-368, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38158078
2.
Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus.
Rheumatology (Oxford)
; 59(9): 2544-2549, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31998961
3.
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
Drug Metab Dispos
; 47(2): 104-113, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30442650
4.
Association between ABCG2 rs2231142 and poor response to allopurinol: replication and meta-analysis.
Rheumatology (Oxford)
; 57(4): 656-660, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342288
5.
Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout.
Mol Biol Evol
; 33(9): 2193-200, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27352852
6.
Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol.
Ann Rheum Dis
; 75(6): 1074-80, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26742777
7.
Urate Handling in the Human Body.
Curr Rheumatol Rep
; 18(6): 34, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27105641
8.
No association between ATP-binding cassette transporter G2 rs2231142 (Q141K) and urate-lowering response to febuxostat.
Rheumatology (Oxford)
; 58(3): 547-548, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30597115
9.
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
Rheumatology (Oxford)
; 53(12): 2167-74, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24509406
10.
Plasma oxypurinol as a measure of adherence in clinical trials.
Ann Rheum Dis
; 77(2): 313-314, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28057666
11.
Multimodal NASH prognosis using 3D imaging flow cytometry and artificial intelligence to characterize liver cells.
Sci Rep
; 12(1): 11180, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35778474
12.
Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 21(6): 1697-700, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316964
13.
Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.
Bioorg Med Chem Lett
; 21(1): 168-71, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21115247
14.
Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts.
BMC Cancer
; 10: 515, 2010 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20920162
15.
Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.
Proc Natl Acad Sci U S A
; 104(49): 19244-9, 2007 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032610
16.
The search for safer glucocorticoid receptor ligands.
Endocr Rev
; 26(3): 452-64, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15814846
17.
Cell-specific activation of the human skeletal alpha-actin by androgens.
Endocrinology
; 149(3): 1103-12, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18063690
18.
LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo.
Endocrinology
; 149(5): 2080-9, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18218700
19.
Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.
Bioorg Med Chem Lett
; 18(12): 3504-8, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18513967
20.
Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy Japanese and non-Asian male subjects.
Drug Des Devel Ther
; 12: 1799-1807, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29950814