RESUMO
In this work the Authors have tried to show the efficacy of TMX, as a miotic drug, and to find out the lowest concentration which can give the best results with the minor complications. Seven patients, in whom TMX was instilled in both eyes at 0.50%, 1%, 2% concentrations, were studied. A mydriatic was instilled before in the right eye, in order to obtain mydriasis whereas the left eye served as control. The 0.5% concentration was as efficacious as 1% and 2% ones, but had less side-effects.
Assuntos
Mióticos , Moxisilita/administração & dosagem , Administração Tópica , Relação Dose-Resposta a Droga , Humanos , Midriáticos/uso terapêutico , Fatores de TempoRESUMO
PURPOSE: To characterise the association between lens phacoemulsification and the development of macular edema. METHODS: We studied 15 patients who underwent lens phacoemulsification in our clinic between January and April 1998 performed by the same surgeon. Ultrasound power and cumulative time was noted. Follow-up was performed at 1 day, 1 week, 1, 3 and 6 months after operation. On each visit corneal thickness, best corrected visual acuity, biomicroscopy and fluorescein angiography were performed. Patients with systemic diseases and/or retinal diseases were not included. RESULTS: Visual acuity was inversely related to the amount of energy delivered during phacoemulsification. In patients who had received more than 1 Joule of energy, fluorescein angiography revealed a higher incidence of blood retinal barrier breakdown. Corneal thickness was not correlated with the ultrasound energy used. CONCLUSIONS: Excessive use of power during phacoemulsification may hamper the postoperative evolution of cataract surgery.
Assuntos
Macula Lutea/patologia , Edema Macular/etiologia , Facoemulsificação/efeitos adversos , Ultrassonografia de Intervenção/efeitos adversos , Idoso , Feminino , Angiofluoresceinografia , Fundo de Olho , Humanos , Incidência , Macula Lutea/diagnóstico por imagem , Macula Lutea/cirurgia , Edema Macular/diagnóstico , Edema Macular/epidemiologia , Masculino , Pessoa de Meia-Idade , Facoemulsificação/métodos , Estudos Retrospectivos , Acuidade VisualRESUMO
The Authors have studied in a homogeneous group of rabbits the variations of intraocular pressure and of aqueous humour pH caused by instillation of timolol maleate at different concentrations. In the animals treated with drug concentration of 0,25% and 0,5% a constant reduction of IOP has been observed in comparison with controls, associated to acidification of aqueous humour: no evidence of this correlation it seems to be at low doses of timolol. Further studies are in course to indicate an eventual action of intermediate substances in the mechanism of IOP depression caused by timolol.