RESUMO
The authors report a case of a 4-year-old child whose death resulted from acute lymphoblastic leukemia (ALL) and giant-cell pneumonia. Typical lung tumorlets were occasionally observed. On electron microscopy study it was possible to demonstrate a large number of neurosecretory granules in the tumorlet's cells, identical to those present in Kulchitsky's cells. These studies suggest the occurrence of an abnormal immunitary process.
Assuntos
Leucemia Linfoide/complicações , Neoplasias Pulmonares/complicações , Neoplasias Primárias Múltiplas/complicações , Fibrose Pulmonar/complicações , Pré-Escolar , Humanos , Terapia de Imunossupressão , Neoplasias Pulmonares/etiologia , Neoplasias Pulmonares/patologia , Vírus do Sarampo , Fibrose Pulmonar/etiologia , Fibrose Pulmonar/patologiaRESUMO
The number of mast cells in the islets of Langerhans in 60 cases was determined in an autopsy study. The 60 patients were divided into 4 groups, distinguishing between those with diabetes, insular amyloidosis, those with both these pathological conditions and those with neither diabetes nor insular amyloidosis. As compared with the control group, it was discovered that there was a sharp increase in mast cells in the group with insular amyloidosis and in the group with diabetes; the number of mast cells tended to increase even more in the presence of both pathological conditions. With these data in hand, it is assumed that the increase in mast cells in the islets of Langerhans is not only due to the presence of amyloidosis, but that it is also brought about as a direct consequence of diabetes.
Assuntos
Amiloidose/patologia , Diabetes Mellitus/patologia , Ilhotas Pancreáticas/patologia , Mastócitos , Fatores Etários , Idoso , Autopsia , Contagem de Células , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The results of a study of eighty-two human pancreases affected by deposits of amyloid in the islets of Langerhans are presented. Two different types of amyloid deposits were observed, one affecting the exocrine tissue and the other affecting the islets. These deposits were found to be histochemically different and appeared to indicate two different aetiopathogenetic processes. The deposit found in the exocrine tissue is essentially perivascular and might be considered an extension to the pancreas of a systemic amyloidosis of the "senile type"; the islet deposits appear to be a completely different phenomenon that could become part of the biology and pathology peculiar to the so called APUD system. The coexistence of the two types of amyloid in the human pancreas would seem, therefore, to represent a casual event.